ATP结合匣式转运子G2(ATP-Binding Cassette Family G2 Transporters,ABCG2)是胎盘表达的主动转运因子之一,ABCG2的生理作用是保护组织免受内源性毒素或异生物质的损害和维持细胞稳态.ABCG2在人胎盘中高表达,位于合体滋养细胞膜面向母血侧,可以有效地形成母胎循环间的屏障,限制药物、内毒素及异生物质透过胎盘而对胎儿产生影响,并与胎盘分化、细胞凋亡及一些妊娠并发症如子痫前期、妊娠期糖尿病、绒毛膜羊膜炎及胎儿生长受限的发生发展及治疗有关,了解ABCG2有重要的临床意义.综述ABCG2的结构、功能及其在产科领域的研究进展.%ATP-Binding Cassette Family G2 Transporters (ABCG2) is one of the active transporters in the placenta. It can not only resist the drugs entering cells, but also transport a variety of harmful toxic chemicals away from body. The physiological function of ABCG2 is likely to protect tissues from endogenous toxin or different xenobiotics and remain the cellular environmental homeostasis, ABCG2 is highly expressed in human placenta,it is located in the apical membrane of syncytiotrophoblast cell facing the mother side and form a barrier effectively in the maternal-fetal interface, limiting drugs, endogenous toxin and xenobiotics which possibly affect the fetus through the placenta. ABCG2 is also participate in the differentiation of placenta and cell apoptosis and some complications of pregnancy such as preeclampsia, gestational diabetes, chorioamnionitis and fetal growth restriction, etc. As a drug transporter, ABCG2 is related to the therapy of these complications during pregnancy. It is important to know more about ABCG2 for its important clinical significance. The structure and function of the ABCG2 and its roles in the field of obstetrics were reviewed in this paper.
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