Autophagy is called "Type II Programmed Cell Death" in which the cell digests damaged organelles and molecules with lysosomal system and maintains energy cycling. The dysfunction of autophagy is related to cancer. Ovarian cancer is of great malignance. While most of patients are diagnosed with advanced stage and will eventually relapse, the 5-year survival rate is approximately 20%-25%. It is investigated that autophagy has some connection with the carcinogenesis, prognosis and treatment of ovarian cancer. Some autophagy-related genes such as Beclin 1 were shown downregulated in ovarian cancer tissue, while overexpression of PEA-15, an autophagy-related protein, was reported to be associated with longer survival rate in women with ovarian cancer, and thus to be a potentially promising prognostic biomarker. The role of autophagy in the management of ovarian cancer is still debating. This review aims to address the progression of autophagy in ovarian cancer.%自噬是细胞利用溶酶体消化受损细胞器及大分子物质并为细胞提供能量的过程,被称为“Ⅱ型程序性死亡”,其功能异常与肿瘤的发生、发展密切相关.卵巢癌是妇科肿瘤中恶性程度极高的一种,由于多数患者诊断时已为晚期,且术后常易复发,其5年生存率仅为20％～25％.有研究发现,自噬与卵巢癌的发生、预后及治疗相关,Beclin1等多种自噬相关基因在卵巢癌中表达下调,高表达自噬相关蛋白PEA-15的卵巢癌患者生存期更长,有望成为卵巢癌新的预后指标,而在卵巢癌的治疗过程中自噬究竟起抑制还是促进肿瘤生长的作用,尚无定论.现就自噬与卵巢癌的关系的研究进展进行综述.
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