Objective:To investigate the effect of hemabate on the hemostasis and oxidative stress in patients with placenta previa who undergoing cesarean delivery.Methods:Ninety-eight patients with placenta previa who undergoing cesarean delivery and postpartum hemorrhage in our hospital from January 2015 to February 2017 were retrospectively analyzed.According to the treatment methods,they were divided into the control group (51 cases) and the observation group (47 cases).The control group received the intrauterine packing hemostasis,and the observation group received a hemabate injection (250 μg) in corpus uteri besides the packing hemostasis.The bleeding volume,oxidative stress level and stress hormone were tested.Results:The blood loss in operation,2 h postpartum and 24 h postpartum in the observation group were significantly lower than those in the control group (P＜0.05).The postoperative levels of serum ROS and MDA in both groups were significantly higher than the preoperative levels,and the postoperative levels of SOD and CAT were lower than the preoperative levels (P＜0.05).The postoperative levels of ROS and MDA in the observation group were significantly lower than those in the control group,and the postoperative levels of SOD and CAT were higher in the observation group than in the control group (all P＜0.05).The postoperative levels of NE,E and Cor in both groups were significantly higher than those preoperative levels,while the postoperative levels of NE,E and Cor in the observation group were lower than those in the control group (all P＜0.05).Conclusions:Hemabate injection in corpus uteri as the adjuvant therapy of pre-placental hemorrhage can effectively reduce the blood loss and oxidative stress,suggesting the potential application of hemabate.%目的:探讨欣母沛对前置胎盘剖宫产患者的止血效果及氧化应激水平的影响.方法:回顾性分析2015年1月-2017年2月青海省人民医院前置胎盘行剖宫产产后出血患者98例,依据治疗方法分为对照组(51例)和观察组(47例),对照组给予宫腔纱条填塞(宫纱填塞)止血治疗,观察组在对照组的基础上给予欣母沛注射液.对2组患者的出血量、氧化应激水平及应激激素水平进行检测.结果:观察组患者术中、产后2h及产后24 h出血量均显著低于对照组,差异有统计学意义(P＜0.05);2组患者术后活性氧簇(ROS)及丙二醛(MDA)水平均较术前升高,超氧化物歧化酶(SOD)及过氧化氢酶(CAT)水平均较术前降低,差异有统计学意义(P＜0.05);观察组术后ROS及MDA水平均低于对照组,SOD及CAT水平均高于对照组,差异有统计学意义(P＜0.05);2组患者术后去甲肾上腺素(NE)、肾上腺素(E)及皮质醇(Cor)水平均较术前升高,差异有统计学意义(P＜0.05);术后观察组NE、E及Co冰平均低于对照组,差异有统计学意义(P＜0.05).结论:欣母沛注射液辅助治疗前置胎盘产后出血效果显著,且能有效降低患者氧化应激水平,减轻应激反应,值得临床进一步推广使用.
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