Objective：To evaluate the role of plasma interleukin（IL）-10 family（IL-10,IL-19 and IL-20） in patients with unstable angina.Methods：Peripheral blood was collected from 52 patients with coronary heart disease,including 36 patients with unstable angina pectoris（UAP group）and 16 patients with stable angina pectoris（SAP group）.Selecting 20 cases healthy,age and gender matched,as controls（control group）.IL-10,IL-19 and IL-20 concentrations were measured by ELISA.Results：The level of IL-10 was found to be lower in UAP group compared with the SAP group and the control group（both P0.01）.The levels of IL-10 of the SAP group and the control group were no significant difference（P0.05）.The level of IL-19 was found to be higher in UAP group and SAP group compared with the control group（respectively P0.01 and P0.05）.The level of IL-20 was found to be higher in UAP group and SAP group as compared with the control group（both P0.01）.The levels of IL-19 and IL-20,especially,were found to be increased in UAP group compared with SAP group（both P0.05）.Conclusion：The research suggests that the down-regulation of IL-10 and the up-regulation of IL-19 and IL-20 may play an import role in the progression of atherosclerosis plaque unstability and the clinical sign of unstable angina patients.%目的：探讨血浆白细胞介素（IL）-10家族成员IL-10、IL-19和IL-20水平与不稳定型心绞痛的关系.方法：冠心病患者52例,其中36例不稳定型心绞痛患者（UAP组）,16例稳定型心绞痛患者（SAP组）.同期江汉大学附属医院健康体检者20例作为对照组.采用ELISA法检测上述患者血浆中IL-10、IL-19及IL-20水平.结果：UAP组患者血浆IL-10水平较SAP组和对照组显著降低（P〈0.01）,而SAP组和对照组血浆IL-10水平差异无统计学意义（P〉0.05）.与对照组相比较,UAP组和SAP组患者血浆IL-19水平显著升高（分别为P〈0.01和P〈0.05）;与SAP组相比,UAP组患者血浆IL-19水平显著升高（P〈0.05）.与对照组相比较,UAP组和SAP组患者血浆IL-20水平显著升高（P〈0.01）;与SAP组相比,UAP组血浆IL-20水平显著升高（P〈0.05）.结论：血浆IL-10水平降低和IL-19及IL-20水平升高可能导致了冠状动脉粥样硬化斑块的不稳定和UAP患者临床症状的发生.
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