Objective To determine whether Photodynamic therapy (PDT) with Indocyanine green (ICG) has harmful effect on corneal endothelium in rabbit for prevention of posterior capsule opacification ( PCO). Methods 32 rabbit s eyes were randomly divided in 4 groups: control group, low dose group, middle dose group and high dose group. Extracapsular lens extraction by phacoemulsification was performed on 32 eyes. 0.5 ml ICG (1.25 mg/mL, 2.5 mg/mL, 5 mg/mL) was injected in the capsular bag and the eye was illuminated with a diode laser (wavelength 810 nm) for 2min. 3 months after surgery, the number of corneal endothelia cells and the sickness of cornea were observed. Results 3 months after surgery, the number of corneal endothelia cells in low dose group, middle dose group and high dose group reduced, but had no statistically significant difference with control group. 3 months after surgery, the sickness of cornea in low dose group, middle dose group and high dose group increased, but had no statistically significant difference with control group. Conclusion Indocyanine green guided photodynamic prevention of posterior capsular opacification has no effect on rabbit corneal endothelial cells.%目的 研究吲哚青绿介导光动力防治后囊膜浑浊对兔角膜内皮细胞的影响.方法 32只兔眼随机分为对照组、低剂量组、中剂量组、高剂量组,分别行晶状体超声乳化皮质吸出术；低、中、高剂量组皮质吸出后前房内分别注入0.5 mL浓度为1.25 mg/mL,2.5 mg/mL,5 mg/mL的吲哚青绿(ICG)后用810 nm的半导体激光对囊膜进行低能量(50 wm/cm)照射2 min.术后3月时观察角膜内皮细胞的数量和角膜的厚度.结果 术后3月,低剂量组、中剂量组、高剂量组的角膜内皮细胞数量发生减少,但是与对照组相比,差异无统计学意义；术后3月,低剂量组、中剂量组、高剂量组的角膜厚度增加,但是与对照组相比,差异无统计学意义.结论 吲哚青绿介导光动力防治后囊浑浊对兔角膜内皮细胞没有影响.
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