Objective To discuss the effects of explosion shock wave by explosive ammunition on some hormones contents of rats. Methods TNT ammunition was used as explosion source, and the rats were placed in the position 12 meter away from explosion center. 12h, 24h, 3days, 7days and 14days after explosion, rats' blood was taken, and some serum hormones contents were administrated by u-sing radio immunoassay. Results 12h after explosion, compared with control, the contents of ACTH, ALD, CORT and T increased significantly, and then, decreased gradually (low point at 7Hays after explosion) and increased again at 14days after explosion. The content of T3 showed no significant change and T4 decreased significantly. Conclusion The explosion shock wave can change rats' serum hormones contents of pituitary - adrenal axis and pituitary - gonadal axis, but pituitary - thyroid axis changes a little.%目的 探讨爆炸性弹药爆炸时产生的冲击波对大鼠部分激素含量的影响.方法 以三硝基甲苯( trinitro tolune,TNT)弹药为爆炸源,将大鼠布放在距爆心12m处,于爆后不同时间(爆后12h、24h、3天、7天、14天)采血,用放射免疫法检测大鼠血清中部分激素含量.结果 爆后12h,大鼠血清中促肾上腺皮质激素(adrenocorticotropin hormone,ACTH),醛固酮(aldosterone,ALD),皮质醇(cortisol,CORT)和睾酮(testosterone,T)的含量明显升高,随后逐渐降低,至爆后7天时降至较低点,爆后14天时再次升高.而三碘甲腺原氨酸( tiiodothyronine,T3)无明显变化,甲状腺素(thyroxine,T4)则出现明显降低.结论 爆炸冲击波将引起大鼠垂体-肾上腺轴和垂体-性腺轴部分血清激素含量的明显变化,而对垂体-甲状腺轴激素含量影响较小.
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