目的：：探讨人群中抗中性粒细胞胞浆抗体(ANCA)的检出情况。方法：采用间接免疫荧光(IIF)法和 ELISA 法对1318例疑似原发性小血管炎患者做 ANCA、肝功能、肾功能指标检测,并进行分组统计分析。结果：1318例患者中检出 ANCA 阳性21例,阳性率为1.59%,其中 p-ANCA 阳性16例,阳性率1.21%,c-ANCA 阳性5例,阳性率0.38%；抗-MPO 阳性16例,阳性率1.21%；抗-PR3阳性5例,阳性率0.38%。对研究对象进行性别分组统计：男性患者635例,检出 ANCA 阳性11例占1.73%,女性患者683例,检出 ANCA 阳性10例占1.46%,两者无统计学差异(P >0.05)；年龄分组统计：30岁以下184例,检出 ANCA 阳性1例,占0.54%,30岁以上1134例,检出 ANCA 阳性20例占1.76%,经χ2检验,两者有显著统计学差异(P <0.01)；21例 ANCA 阳性患者中有17例肾功能明显异常占80.95%。结论：本地区疑似原发性小血管炎患者 ANCA 检出率为1.59%,以 P-ANCA 和抗-MPO 为主,中老年组ANCA 阳性率明显高于儿童青少年组,ANCA 抗体与性别关系不明显；ANCA 相关患者大多肾功能受损较严重。%Objective:To investigate the detection of anti neutrophil cytoplasmic antibodies (ANCA)in the population. Methods:ANCA,liver function and renal function indexes were detected by indirect immunofluorescence (IIF)method and ELISA method in 1 318 patients with suspected primary small vessel vasculitis.Results:1 318 patients with positive ANCA positive in 21 cases,the positive rate was 1.59%,1 6 cases of them were p-ANCA positive,positive rate of 1.21%,c-ANCA positive 5 cases,positive rate of 0.38%;anti MPO positive in 1 6 cases,the positive rate of 1.21%;an-ti-PR3 5 cases were positive,positive rate of 0.38%.Gender statistical grouping of the research object:635 cases of male patients,the detection ANCA positive in 1 1 cases (1.73%),683 cases of female patients,the detection 10 cases of ANCA positive accounted for 1.46%.Both of them had no significant difference (P >0.05);age group statistics:184 cases were under 30 years old,1 case of detection of ANCA positive(0.54%),above 30 years old in 1 134 cases detec-tion ANCA positive in 20 cases (1.76%),by χ2 test,both have a significant statistical difference (P <0.01 ),21 pa-tients with ANCA positive patients,1 7 cases of renal function was abnormal 80.95%.Conclusion:Local area suspected of primary small vessel vasculitis patients with ANCA detection rate was 1.59%,with P-ANCA and anti MPO mainly, positive rate of ANCA in the elderly group was significantly higher than that in children and adolescents group and ANCA antibodies and gender relations is not obvious;ANCA associated with most renal damage more serious.
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