Objective:To investigate the clinical and pathological factors associated with colorectal cancer liver metastasis.Methods:Collected clinical data from 2010 to 2014 in Drum Tower Hospital of Nanjing University of gen-eral surgery patients with colorectal cancer 201 cases,analyze the relationship between liver metastases of colorectal cancer and clinical pathological factors.Results:Of 201 patients with colorectal cancer,liver metastasis developed in 45 cases.Univariate analysis showed that tumor size,CEA,CA199,CA125,tumor T stage,tumor differentiation,patho-logical type,diabetes,tumor location,smoking were risk factors of liver metastases of colorectal cancer.Logistic multi-variate analysis showed that CEA,CA199,CA125,tumor differentiation,pathological type,diabetes were independent risk factors for liver metastasis.Conclusion:CEA,CA199,CA125,tumor differentiation,pathological type,diabetes are independent risk factors for liver metastasis.%目的：探讨影响结直肠癌肝转移的临床病理相关因素。方法：收集2010年至2014年南京大学鼓楼医院普外科结直肠癌患者201例的临床病理资料，分析同时性结直肠癌肝转移与临床病理因素的关系。采用非条件Logistic回归单因素分析，对有统计学意义的变量进行非条件Logistic回归多因素分析。结果：201例结直肠癌患者中，肝转移45例。单因素分析显示，肿瘤最大径、CEA、CA199、CA125、肿瘤T分期、分化程度、病理组织类型、糖尿病、肿瘤位置、吸烟是影响结直肠癌肝转移的危险因素。Logistic多因素分析，结果显示肿瘤最大径、CEA、CA199、CA125、肿瘤分化程度、病理类型、糖尿病是肝转移的独立危险因素。结论：肿瘤最大径、CEA、CA199、CA125、肿瘤分化程度、病理类型、糖尿病是同时性结直肠癌肝转移的独立危险因素。
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