目的 检测抑郁症患者血清维生素B12、叶酸的水平并探讨其与健康人群的差异.方法 采用电化学发光免疫分析方法对148例抑郁症患者(抑郁症组)和160例健康人群(健康对照组)进行血清维生素 B12和叶酸的测定,比较抑郁症组与健康对照组血清维生素B12和叶酸水平.结果 抑郁症组血清维生素B12和叶酸的质量浓度分别为(527.28±173.74)pg·mL-1和(7.03±3.52)ng·mL-1,健康对照组血清维生素B12和叶酸的质量浓度分别为(669.67±336.89)pg·mL-1和(7.93±4.00)ng·mL-1,抑郁症组血清维生素 B12和叶酸水平均低于健康对照组(P=0.000,P=0.038).结论 抑郁症患者的血清维生素B12和叶酸水平低于健康人群.%Objective To detect serum levels of folic acid and vitamin B12in patients with de-pression,and to investigate their differences between depression patients and healthy persons. Methods Serum folic acid and vitamin B12levels were detected by electrochemiluminescence im-munoassay in 148 depression patients(depression group)and 160 healthy subjects(control group).Results The concentrations of vitamin B12and folic acid in depression group((527.28± 173.74)pg·mL-1and(7.03±3.52)pg·mL-1,respectively)were lower than those in control group((669.67±336.89)pg·mL-1and(7.93±4.00)ng·mL-1,respectively)(P=0.000 and P=0.038,respectively).Conclusion Serum folic acid and vitamin B12levels in depression pa-tients are lower than those in healthy persons.
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