目的：探讨黄芪注射液对儿童原发性肾病综合征（primary nephrotic syndrome，PNS）高凝状态的影响。方法将41例PNS患儿随机分为治疗组21例、对照组20例。2组均给予泼尼松片1．5～2 mg·kg-1·d-1口服治疗，在常规激素治疗基础上治疗组给予黄芪注射液1 mL · kg-1· d-1静脉滴注治疗，对照组给予阿司匹林1～3 mg· kg-1· d-1口服治疗。15 d 为1个疗程，2组均治疗2个疗程。结果2组治疗后血生化指标血尿素氮（BUN）、肌酐清除率（Ccr）、血肌酐（Scr）、血浆清蛋白（A1b）、总胆固醇（TC）、三酰甘油（TG），24 h尿蛋白定量及血液高凝状态指标血纤维蛋白原降解产物（FDP）、血浆纤维蛋白原（FIB）浓度、血 D-二聚体（D-D）较治疗前均显著改善（P＜0．01），且治疗组改善效果明显优于对照组，差异有统计学意义（P＜0．05）；2组凝血酶原时间（PT）指标治疗前后比较差异无统计学意义（P＞0．05）。结论黄芪注射液对PNS患儿高凝状态有显著疗效，同时可降低蛋白尿，保护肾功能。%Objective To investigate the effect of astragalus injection on hypercoagulation state in children with primary nephrotic syndrome(PNS).Methods Forty-one children were randomly divided into treatment group(n=21)and control group(n=20).All patients were treated with o-ral prednisone tablets (1 .5-2 mg · kg-1 · d-1 ).In addition,treatment group and control group were given two 15-day cycles of intravenous infusion of astragalus injection(1 mL·kg-1·d-1) and oral aspirin(1-3 mg·kg-1 ·d-1 ),respectively.Results Blood urea nitrogen,creatinine clear-ance rate,serum creatinine,plasma albumin,total cholesterol,triacylglycerol,24-hour protein ex-cretion,fibrinogen degradation products,plasma fibrinogen and D-dimer were significantly im-proved after treatment in both group(P<0.01),and the improvement in treatment group was more obvious than that in control group(P<0.05).No significant changes in prothrombin time were found after treatment in both groups(P>0.05).Conclusion Astragalus injection is effec-tive for hypercoagulation state and can reduce albuminuria and protect renal function in children with PNS.
展开▼
