Objective To investigate the effect of edaravone on inflammatory cytokine balance during the perioperative period in patients undergoing radical treatment for pulmonary carcinoma. Methods Forty-eight patients undergoing elective radical treatment for pulmonary carcinoma were randomly divided into control group and observation group,with 24 patients in each group. Anesthesia was induced with midazolam 0.03 mg·kg-1,sufentanil 0.5μg·kg-1,vecuronium 0.1 mg·kg-1 and 8% sevoflurane,and was maintained with sevoflurane 1.8%-2.7% end-tidal, intermittent vecuronium bromide 0.04-0.08 mg·kg-1 and sufentanil 5-10μg in both groups.Fur-thermore,control group and observation group received edaravone 0.5 mg·kg-1 and the same volume of saline after anesthesia induction,respectively.Patient-controlled intravenous sufentanil analgesia was performed in all patients for postoperative pain relief.Venous blood samples were taken before anesthesia induction (T0 ),1 hour after one-lung ventilation (T1 ),1 hour after lung expansion (T2 ),2 hours after operation (T3 ),6 hours after operation (T4 )and 24 hours after op-eration (T5 )for the determination of plasma TNF-α,IL-6,IL-1βand IL-10 concentrations.In ad-dition,ratios of TNF-α/IL-10,IL-6/IL-10 and IL-1β/IL-10 were calculated.Results Compared with T0 ,plasma levels of TNF-α,IL-6,IL-1βand IL-10 and ratios of TNF-α/IL-10,IL-6/IL-10 and IL-1β/IL-10 significantly increased at T1-T5 in both group (P<0.05).Compared with control group,plasma levels of TNF-α,IL-6 and IL-1βand ratios of TNF-α/IL-10,IL-6/IL-10 and IL-1β/IL-10 decreased but IL-10 levels increased in observation group (P<0.05).Conclusion Surgical trauma can lead to inflammatory response through inducing the imbalance between pro-and anti-inflammatory cytokines.Edaravone can effectively inhibit the excessive inflammatory response and maintain a balance between pro-and anti-inflammatory cytokines during the perioperative period in patients undergoing radical treatment for pulmonary carcinoma.%目的：评价依达拉奉对肺癌根治术围术期炎性细胞因子平衡的影响。方法将48例择期行肺癌根治术患者按随机数字表法分为对照组与观察组，每组24例。麻醉诱导：2组均静脉注射咪达唑仑0．03 mg·kg-1、舒芬太尼0．5μg·kg-1、维库溴铵0．1 mg·kg-1、吸入8％七氟醚。观察组于麻醉诱导后给予依达拉奉0．5 mg·kg-1，对照组给予等容量生理盐水；麻醉维持：2组均维持七氟醚呼气末浓度1．8％～2．7％，间断静脉注射维库溴铵0．04～0．08 mg·kg-1、舒芬太尼5～10μg；术毕2组均采用舒芬太尼患者自控静脉镇痛。分别于麻醉诱导前（T0），单肺通气1 h（T1），膨肺后1 h（T2），术后2 h（T3）、6 h（T4）和24 h（T5）时采取静脉血样，采用Elisa法测定血浆TNF-α、IL-6、IL-1β及IL-10浓度，并计算TNF-α/IL-10、IL-6/IL-10及IL-1β/IL-10比值。结果与T0比较，T1-T5时点2组血浆TNF-α、IL-6、IL-1β、IL-10浓度及TNF-α/IL-10、IL-6/IL-10、IL-1β/IL-10比值均显著升高（均P＜0．05）；与对照组比较，观察组血浆T1-T5时点 TNF-α、IL-6、IL-1β浓度及 TNF-α/IL-10、IL-6/IL-10及 IL-1β/IL-10比值均显著降低，而 IL-10浓度显著升高（均P＜0．05）。结论手术创伤可导致促炎细胞因子和抗炎性细胞因子比例失衡诱发机体炎性反应；依达拉奉可有效抑制过度炎性反应，使肺癌根治术患者围术期促炎细胞因子和抗炎性细胞因子比例处于相对平衡状态。
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