目的 分析非酒精性脂肪肝(NAFLD)与2型糖尿病(T2DM)患者临床指标及血管病变的关系.方法 选取住院T2DM患者214例,根据肝脏B超结果分为NAFLD组(合并NAFLD,n=116)和非NAFLD组(未合并NAFLD,n=98),回顾性分析2组患者的临床指标和血管病变发生情况.结果 NAFLD组较非NAFLD组体质指数(BMI),收缩压(SBP)、舒张压(DBP),血三酰甘油(TG)、γ-谷氨酰转移酶(GGT)、丙氨酸氨基转移酶(ALT)显著增高(P＜0.05或P＜0.01);Logistic 多元回归分析显示SBP、TG、GGT是NAFLD的独立危险因素(P＜0.05或P＜0.01);NAFLD组大血管和微血管病变发生率显著高于非NAFLD组(P＜0.05或P＜0.01).结论 合并NAFLD的T2DM患者有明显的代谢综合征表现及肝酶升高,且糖尿病大血管和微血管病变发生率明显升高.%Objective To analyze the relationship of nonalcoholic fatty liver disease (NAFLD) to clinical parameters and vascular lesion in patients with type 2 diabetes mellitus (T2DM). Methods According to the results of ultrasound examination, 214 hospitalized patients with T2DM were divided into NAFLD group (n=116) and non-NAFLD group (n=98). Clinical parameters and vascular lesion of patients were analyzed retrospectively. Results Compared with non-NAFLD group, NAFLD significantly increased body mass index (BMI),systolic blood pressure (SBP), diastolic blood pressure (DBP),levels of triglyceride (TG), γ-glutamyltransferase(GGT) and alanine aminotransferase (ALT), and incidence of macrovascular and microvascular disease ( P<0.05 or P<0.01). Logistic regression analysis showed that SBP, TG and GGT were the independent risk factors for NAFLD ( P<0.05 or P<0.01). Conclusion T2DM patients with NAFLD have obvious metabolic syndrome with elevated liver enzymes and macrovascular and microvascular complications.
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