Objective To investigate the clinical significance of thrombin-activatable fibrinoly-sis inhibitor (TAFI) detection in patients with pulmonary embolism. Methods Plasma TAFI Ag levels and TAFI activity (TAFI-a)were determined in 125 patients with massive pulmonary em-bolism (group Al),131 patients with submassive pulmonary embolism (group A2),124 patients with low risk embolism (group A3) and 140 heathy controls. Results Compared with heathy con-trols, TAFI Ag levels and TAFI-a significantly increased in patients with pulmonary embolism (P <0. 001). Moreover, there were significant differences among group Al,group A2 and group A3 (P<0. 05). Conclusion Plasma TAFI detection is valuable in the diagnosis and treatment of pul-monary embolism.%目的 探讨肺栓塞患者血浆凝血酶可激活的纤溶抑制物(TAFI)水平的临床意义.方法 380例肺栓塞患者,其中大面积肺栓塞125例(A1组),次大面积肺栓塞131例(A2组),低危栓塞患者124例(A3组);选取同期健康体检人员140例为正常对照组(B组).检测血浆TAFI抗原(TAFI-Ag)和TAFI活性(TAFI-a)水平.结果 血浆TAFI-Ag和TAFI-a水平比较:A1、A2、A3组显著高于B组,差异有统计学意义(P<0.001);A1、A2、A3组组间比较,差异有统计学意义(P<0.05).结论 检测血浆TAFI水平对肺栓塞诊治有一定的应用价值.
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