目的 分析不同性别成人原发性IgA肾病(IgA nephropathy,IgAN)临床病理特征.方法 回顾性调查2008年5月至2011年12月374例经肾活检确诊为原发性IgAN患者的临床病理资料,分析不同性别原发性IgAN患者的临床表现和病理特征差异性.结果 不同性别原发性IgAN患者的发病年龄、24 h尿蛋白定量、血胆固醇、血白蛋白、血IgA、血C3、血糖水平差异无统计学意义(均P＞0.05),而男性患者收缩压、舒张压、血肌酐、血尿酸及血三酰甘油水平明显高于女性(均P＜0.05);肾小球滤过率(eGFR)显著低于女性(P＜0.05).男女患者在肾小球积分、肾小管积分、肾小动脉积分差异无统计学意义(均P＞0.05),但男性患者肾间质积分和总积分指标显著高于女性患者(均P＜0.05).结论 不同性别原发性IgAN患者临床和病理特征存在一定差异.性别是导致原发性IgAN临床表现多样性的原因之一.%Objective To analyze the clinicopathological differences of primary IgA nephropathy (IgAN) in adult patients of different gender. Methods Clinical and pathological data of 374 IgAN patients diagnosed by renal biopsy from May 2008 to December 2011 were retrospectively analyzed to investigate the differences in clinical manifestations and pathological features between male patients and female patients. Results There were no remarkable differences in onset age, 24 h urinary protein excretion, levels of blood cholesterol, albumin, IgA, C3 and glucose, and glo-merular,tubular and renal arteriole scores between male patients and female patients (P>0. 05). Compared with female patients, systolic blood pressure, diastolic blood pressure, levels of serum creatinine,blood uric acid and triacylglycerol,renal interstitial scores,and total scores significantly increased,but the estimated glomerular filtration rate obviously decreased in female patients (P< 0. 05). Conclusion There are certain differences in clinicopathological features between IgAN patients of different gender. The gender is one of the reasons for clinicopathological diversity of IgAN.
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