目的 了解住院2型糖尿病(2-DM)患者甲状腺功能状态.方法 检测247例住院的2-DM患者游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)、血糖、糖化血红蛋白(HbA1c)、胆固醇、三酰甘油并进行相关分析.结果 247例2-DM患者中甲状腺功能正常210例(A组)占85.1％(210/247),37例甲状腺功能异常占14.9％ (37/247)中:亚临床甲减27例(B组)占10.9％ (27/247)；亚临床甲亢10例(C组)占4.1％(10/247).甲状腺功能异常发生率女性高于男性(P＜0.05).3组间年龄、病程、HbA1c、餐后2h血糖、三酰甘油比较差异无统计学意义(P＞0.05)；空腹血糖:A组高于C组(P＜0.05),B组与A、C组比较差异无统计学意义(P＞0.05)；胆固醇:B组高于C组(P＜0.05),A组与B、C组比较差异无统计学意义(P＞0.05).结论 住院2-DM患者的甲状腺功能异常发生率较高,以亚临床甲减为主,且女性居多.%Objective To investigate the changes in thyroid function of patients with type 2 diabetes mellitus (2-DM). Methods The concentrations of free T3 (FT3) ,free T4 (FT4) .thyroid stimulating hormone (TSH),blood sugar, HbA1c, cholesterol and triglycerides were detected and analyzed in 247 inpatients with 2-DM. Results Thyroid function was normal in 210 (85. 1%) of 247 patients (group A). Among the other 37 (14. 9%) patients with thyroid dysfunction, 27 (10. 9%) had subclinical hypothyroidism (group B) and 10 (4. 1%) had hyperthyroid (group C). The incidence of thyroid dysfunction in female patients was higher than that in male patients (P< 0.05). There were no statistical differences in age, disease course, HbA1c,2-hour postprandial blood glucose and triglycerides among the three groups(P>0. 05). The levels of fasting blood glucose in group A were higher than those in group C (P<0. 05) ,but no significant differences were observed between group B and group A or group C. The cholesterol levels in group B were higher than those in group Cbut no statistical differences were found between group A and group B or group C(P>0. 05). Conclusion The incidence of thyroid dysfunction is high and subclinical hypothyroid is predominant in patients with 2-DM, especially in females.
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