目的：观察潜阳育阴颗粒对正常麻醉犬肾动脉血流量及血压的影响，初步探讨其治疗高血压肾损害的作用机制。方法应用PowerLab系统记录给予潜阳育阴颗粒低、中、高剂量（3．08、6．15、12．30 g／kg）后0～180 min内不同时段比格犬肾动脉血流量、心输出量和血压的变化。结果潜阳育阴颗粒高剂量组给药后120、180 min动脉收缩压（SBP）显著降低（P＜0．05），给药后90、120、180 min，肾血流量显著升高（P＜0．05）；潜阳育阴颗粒中剂量组给药后120 min，SBP明显下降（P＜0．05），给药后90、120 min，肾血流量明显升高（P＜0．05）；低剂量组给药后180 min内各项指标变化不明显。潜阳育阴颗粒3个剂量组心输出量（CO）均未见明显变化。结论潜阳育阴颗粒主要通过增加肾动脉血流量，保护肾功能，从而降低血压。%OBJECTIVE To study the effects of Qianyang Yuyin Granules(QYG)on blood pressure and renal blood flow in anesthetized normal dogs and the mechanism of hypertensive renal injury treatment.METHODS The renal blood flow,cardiac output(CO)and blood pressures were determined by PowerLab system at 15,30,60,90,120,180 min after QYG(3.08,6. 15,12.30 g/kg)administration,respectively.RESULTS Compared with the control group,QYG(12.30 g/kg)reduced sys-tolic blood pressure(SBP) significantly(P<0.05) at 120 min and 180 min,and increased the renal blood flow(P<0.05~0.01)at 90,180 min;QYG(6.15 g/kg)reduced SBP(P<0.05)at 120 min,and increased the renal blood flow(P<0.05) at 90,120 min.The effects of QYG(3.08 g/kg) were not obvious;The three QYG groups hardly affected CO (P>0.05). CONCLUSION QYG can increase the renal blood flow,improve the renal function and then reduce blood pressure.
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