目的 建立脾气虚变应性鼻炎病证复合模型,探讨脾气虚体质与变应性鼻炎发病的内在联系,为临床运用温阳益气法治疗变应性鼻炎提供实验依据.方法 利用大黄泻下法、饮食不节加劳倦过度等综合因素再加上卵清蛋白建立脾气虚变应性鼻炎动物模型,运用温阳益气的中药进行药物反证.结果 观察模型动物出现的鼻部症状(鼻痒、喷嚏、清涕)、鼻分泌物及血中嗜酸粒细胞(EOS),被动皮肤免疫反应(PCA)试验作用明显、大鼠血清中IL-5、嗜酸性细胞阳离子蛋白(ECP)含量升高(P＜0.01);而经过中药治疗后的模型组症状减轻,大鼠血清中IL-5、ECP含量降低(P<0.01).结论 在同样的致敏原作用下,脾气虚动物较正常动物更易于造成变应性鼻炎模型,而温阳益气方对脾气虚变应性鼻炎模型大鼠有一定治疗效应.%OBJECTIVE To establish a compound model of allergic rhinitis caused by spleen-qi deficiency and to explore the internal relation between spleen-qi deficient constitution and allergic rhinitis so as to provide experimental evidence for applying the method of warming yang and invigorate qi into clinic. METHODS The allergic rhinitis models caused by spleen-qi deficiency was set up though purgative therapy of Dahuang, improper diet, overtiredness as well as ovalbumin and then the method of warming yang and invigorating qi was used to treat the condition. RESULTS The model animals appeared of nasal symptoms (nasal itching, sneezing, and nasal mucus), nasal secretions and blood acidophilus granulocyte (EOS), the passive-cutaneous-anaphylaxis (PCA) test showed obvious positive, and rat serum IL-5, eosinophilic cells cationic protein (ECP) content increased (P ＜ 0.01), After herbal treatment, the symptoms of the model group were reduced, and the content of IL-5 and ECP in rats' serum lowered. CONCLUSION Animals with spleen-qi deficiency are more likely to have allergic rhinitis compared with normal ones under the same condition of sensitization, so warming yang and invigorating qi Fang has certain efficacy in treating allergic rhinitis caused by spleen-qi deficiency.
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