目的:评估改良儿童方案治疗年轻成人费城染色体(Ph)阴性急性淋巴细胞白血病的疗效.方法:纳入2013年1月至2014年9月年轻成人Ph阴性急性淋巴细胞白血病35例,患者均采用改良儿童方案化疗,随访并评估患者疗效.结果:32例(91%)达到完全缓解(complete remission,CR),其中24例维持CR,7例复发,4例死于疾病复发,1例死于感染;24个月无病生存率(disease-free survival,DFS)为68.6%,24个月总生存率(overall survival,OS)为77.1%.结论:适当减低化疗强度的儿童方案治疗年轻成人Ph阴性急性淋巴细胞白血病有较好的疗效和安全性.%Objective:To evaluate efficacy of modified pediatric regimen on young adult Ph-negative acute lymphoblastic leukemia.Methods:35 cases of young adult Ph-negative acute lymphoblastic leukemia were enrolled from January 2013 to September 2014,35 patients were received modified pediatric regimen chemotherapy,follow up and evaluate efficacy.Results:32 cases (91%) achieved complete remission (CR),24 cases maintain CR,7 cases relapsed,4 cases died for relapse,1 case died for infection.24-month disease-free survival (DFS) and overall survival (OS) were 68.6% and 77.1%.Conclusion:Appropriate reduced intensity of pediatric regimen for young adult Ph-negative acute lymphoblastic leukemia has a good efficacy and safety.
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