Objective:To investigate the relationship between the changes of anterior pituitary hormone levels and the prognosis of patients with acute stage of traumatic brain injury.Methods:120 cases of TBI patients in our hospital were selected as experimental group,and 40 cases of healthy subjects were selected as control group.It was measured by enzyme linked immunosorbent assay(ELISA)included prolactin(ACTH),prolactin(PRL),thyroid stimulating hormone(TSH),progesterone(LH)and follicle stimulating hormone(FSH).The serum levels of ACTH,PRL,TSH,LH and FSH were observed in the two groups.Results:The levels of ACTH,PRL,LH and FSH in serum of 1,3,7 d in the experimental group were significantly higher than those in the control group.The serum levels of ACTH,PRL,LH and FSH were significantly higher in the light group,medium group and severe group than that in the control group.The serum levels of ACTH,PRL,LH and FSH in the were medium group higher than that of light group,severe group patients serum ACTH,PRL,LH and FSH levels were significantly higher than the medium group,the differences were statistically significant(P<0.05).The good prognosis and the poor prognosis group in patients with serum ACTH,PRL,LH and FSH levels were significantly higher than the control group.The poor prognosis of serum ACTH,PRL,LH and FSH were higher than that of the good prognosis group,the differences were statistically significant (P<0.05).Conclusion:The level of pituitary hormones in patients with acute TBI is closely related to the degree of disease and prognosis,we can provide theoretical support for the treatment and prognosis of patients by observing these indicators.%目的:探讨垂体前叶激素水平的变化与创伤性颅脑损伤患者急性期预后的关系.方法:选择我院住院治疗的TBI患者120例作为实验组,同期选择健康体检者40例作为对照组.采用酶联免疫吸附法(ELISA)测定血清促肾上腺皮质激素(ACTH)、催乳素(PRL)、促甲状腺激素(TSH)、黄体生成素(LH)以及卵泡刺激素(FSH)的含量.观察两组实验对象血清ACTH、PRL、TSH、LH以及FSH水平.结果:实验组患者1、3、7 d血清的ACTH、PRL、LH以及FSH水平要明显高于对照组;轻型组、中型组以及重型组患者血清的ACTH、PRL、LH以及FSH水平要明显高于对照组;此外,中型组患者的血清的ACTH、PRL、LH以及FSH水平要明显高于轻型组,重型组患者的血清的ACTH、PRL、LH以及FSH水平要明显高于中型组,差异均具有统计学意义(P<0.05).预后良好以及预后恶劣组患者血清的ACTH、PRL、LH以及FSH水平要明显高于对照组;预后恶劣组患者血清的ACTH、PRL、LH以及FSH水平要高于预后良好组,差异均具有统计学意义(P<0.05).结论:TBI急性期患者的垂体前叶激素水平与其疾病程度以及预后关系密切,我们可以通过观察此类指标为患者治疗及预后提供理论支持.
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