Objective To systematically evaluate the efficacy of auricular pressure plus conventional western medicine treatment on patients with primary high blood pressure. Methods The randomized controlled trials (RCTs) about auricular pressure and conventional western medicine in treatment of primary hypertension were searched in PubMed, EMbase, The Cochrane Library,Web of science, CBM, CNKI, VIP, and Wanfang Data from the establishment of databases to March 2015, and other relevant journals and references of the included literature were also searched manually. The screening according to the inclusion and exclusion criteria, data extraction was completed by two reviewers independently and the methodological quality assessment was evaluated according to the Cochrane handbook. Meta-analysis was conducted using RevMan 5.3 software. Results A total of 15 RCTs including 1435 patients were enrolled. In all trials ,the results indicated that auricular pressure plus conventional western medicine treatment could significantly enhance the effective rate of lowering blood pressure [RR=1.17,95%CI(1.12,1.23),P<0.01], improve the clinical curative effective rate[RR=1.29,95%CI(1.16,1.44),P<0.01], reduce the systolic blood pressure of patients [SMD=-0.66,95%CI(-0.86,-0.46), P<0.01] and decrease the diastolic blood pressure of patients [SMD=-0.59,95%CI (-0.79,-0.39), P<0.01]. There were significant differences in the effect comparison between experiment group and control group. Conclusion Auricular pressure plus conventional western medicine treatment is more beneficial than western medicine alone for primary hypertension. In addition, restricted by the normalization and consistency of the study, the clinical promotion should be further verified by more quality clinical research.%目的 评价耳穴贴压联合西药治疗原发性高血压的临床疗效Meta分析.方法 计算机检索PubMed、Embase、The Cochrane Library、Web of Science、中国生物医学文献服务系统、中国期刊全文数据库、万方、维普等数据库,查找关于耳穴贴压联合西药治疗原发性高血压的随机对照试验,并对纳入文献的参考文献进行检索,检索时限为建库至2015年3月.由2位评价员严格按照纳入与标准独立筛选、提取资料,并按照Cochrane handbook中文献质量评价标准,进行方法学质量评价后,采用RevMan 5.3和Stata 12.0进行Meta分析.结果 最终纳入15个随机对照试验,共1435例患者.Meta分析结果显示:与对照组相比,耳穴贴压联合西药能显著提高原发性高血压的降压疗效[RR=1.17,95%CI(1.12,1.23),P<0.01],改善临床症状疗效[RR=1.29,95%CI(1.16,1.44),P<0.01],降低患者收缩压[SMD=-0.66,95%CI(-0.86,-0.46),P<0.01],降低患者舒张压[SMD=-0.59,95%CI(-0.79,-0.39),P<0.01].结论 耳穴贴压联合西药治疗原发性高血压的临床疗效显著优于单纯西药.但受纳入研究规范性、统一性等方面的限制,研究结果的推广还有待更多高质量的随机对照试验加以验证.
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