Inner ear barriers to nanomedicine-augmented drug delivery and imaging

Jing Zou; Ilmari Pyykk€o; Jari Hyttinen

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Inner ear barriers to nanomedicine-augmented drug delivery and imaging

机译：内耳屏障增强了纳米药物的递送和成像

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There are several challenges to inner ear drug delivery and imaging due to the existence of tight biological barriers to the target structure and the dense bone surrounding it. Advances in imaging and nanomedicine may provide knowledge for overcoming the existing limitations to both the diagnosis and treatment of inner ear diseases. Novel techniques have improved the efficacy of drug delivery and targeting to the inner ear, as well as the quality and accuracy of imaging this structure. In this review, we will describe the pathways and biological barriers of the inner ear regarding drug delivery, the beneficial applications and limitations of the imaging techniques available for inner ear research, the behavior of engineered nanomaterials in inner ear applications, and future perspectives for nanomedicine-based inner ear imaging.

机译：由于对目标结构及其周围的致密骨存在紧密的生物屏障，内耳药物的输送和成像面临一些挑战。影像学和纳米医学的进步可能为克服内耳疾病的诊断和治疗方面的现有局限性提供知识。新技术提高了药物递送和靶向内耳的功效以及对该结构成像的质量和准确性。在这篇综述中，我们将描述内耳在药物输送方面的途径和生物学障碍，内耳研究可用的成像技术的有益应用和局限性，工程化纳米材料在内耳应用中的行为以及纳米医学的未来前景的内耳成像。

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《中华耳科学杂志（英文版）》 |2016年第004期|165-177|共13页
作者
Jing Zou; Ilmari Pyykk€o; Jari Hyttinen;
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作者单位

Department of 0tolaryngology e Head and Neck Surgery, Center for 0tolaryngology e Head&Neck Surgery of Chinese PLA, Changhai Hospital, Second Military Medical University, Shanghai, China;

Hearing and Balance Research Unit, Field of 0tolaryngology, School of Medicine, University of Tampere, Tampere, Finland;

Department of Electronics and Communications Engineering, BioMediTech, Tampere University of Technology, Tampere, Finland;

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Inner ear barriers to nanomedicine-augmented drug delivery and imaging

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