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Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection

         

摘要

Coronavirus disease 2019(COVID-19)has been a pandemic for more than a year.With the expanding second wave of the pandemic in winter,the continuous evolution of SARS-CoV-2 has brought new issues,including the significance of virus mutations in infection and the detection of asymptomatic infection.In this review,we first introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19,primarily focusing on their strengths and limitations.We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection.The review finally summarized useful insights into the molecular diagnosis of COVID-19 under the special situation being challenged by virus mutation and asymptomatic infection.

著录项

  • 来源
    《药物分析学报:英文版》 |2021年第3期|257-264|共8页
  • 作者单位

    Institute of Molecular and Translational Medicine(IMTM);

    Department of Biochemistry and Molecular Biology;

    School of Basic Medical Sciences;

    Xi’an Jiaotong University Health Science Center;

    76 West Yanta Road;

    Xi’an;

    Shaanxi;

    710061;

    PR China;

    Key Laboratory of Environment and Genes Related to Diseases(Xi’an Jiaotong University);

    Ministry of Education;

    Xi’an;

    Shaanxi;

    710061;

    PR China;

    Section for Medical Inflammation Research;

    Department of Medical Biochemistry and Biophysics;

    Karolinska Institutet;

    Stockholm;

    17177;

    Sweden;

    School of Pharmacy;

    Xi’an Jiaotong University Health Science Center;

    76 West Yanta Road;

    Xi’an;

    Shaanxi;

    710061;

    PR China;

    Department of Orthopedics;

    The Second Affiliated Hospital of Xi’an Jiaotong University;

    Xi’an;

    Shaanxi;

    710004;

    PR China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 传染病;
  • 关键词

    SARS-CoV-2; Virus variation; Nucleic acid detection; Asymptomatic infection;

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