Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma

Xiaoxv Gao; Baojing Zhang; Xiaochi Ma; Chengpeng Sun; Zhenglong Yu; Jian Cang; Xiangge Tian; Xiaokui Huo; Lei Feng; Xinguang Liu; Chao Wang

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Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma

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In order to clarify regions of production and to discriminate processing methods,quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed.Methodologies included HPLC-PDA,HPLC-VWD and UHPLC-MSn,combined with principal component analysis (PCA) and partial least squares regression techniques (PLSR).The inhibitory effects of triterpenes and Alismatis Rhizoma extracts on lipase activity were evaluated in vitro.PLSR analysis revealed significant positive correlations (R2 =0.5795) between the contents of triterpenes 10,14,15,18 and 22 and the inhibitory effects of Alismatis Rhizoma.The present study establishes an effective method for simultaneous determination of multiple components,and identifies key bioactive triterpenes.These results can be used for systematic and novel analytical strategies for the quality control of Alismatis Rhizoma production.

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《药学学报（英文版）》 |2018年第2期|242-251|共10页
作者
Xiaoxv Gao; Baojing Zhang; Xiaochi Ma; Chengpeng Sun; Zhenglong Yu; Jian Cang; Xiangge Tian; Xiaokui Huo; Lei Feng; Xinguang Liu; Chao Wang;
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College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

College of Pharmacy,Academy of Integrative Medicine,Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China;

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Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma

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