The spectrum of CD30+cutaneous lymphoproliferative disorders (CD30+CLPDs) includes lymphomatoid papulosis (LYP), primary cutaneous anaplastic large-cell lymphoma (PCALCL) and borderline cases that represent the second most common types of CTCL after mycosis fungoides (MF) and comprise approximately 25%of all CTCL. Recent years, reifnement of histopathologic type, etiology research, abnormal lymphocyte apoptosis and abnormal gene expression provided new insights into the pathogenesis and therapy of CD30+CLPDs.%皮肤CD30+淋巴增殖性疾病是仅次于蕈样肉芽肿的第二大类最常见的皮肤T细胞淋巴瘤，其发病率占原发性皮肤T细胞淋巴瘤的25%左右。该病是一种病谱性的疾病，临床上包括淋巴瘤样丘疹病和原发性皮肤间变性大细胞淋巴瘤以及其中的中间类型。近年来对皮肤CD30+淋巴增殖性疾病组织病理类型的细化、发病的病因学、淋巴细胞凋亡异常以及基因异常的研究，为揭示皮肤CD30+淋巴增殖性疾病发病以及治疗提供了一些新的观点。
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