Objective To study the clinical significance and expression of DAB2IP in colorectal cancer. Methods Immunohistochemical study was applied to detect DAB2IP protein in 103 cases of colorectal cancer tissues, normal mucosae and metastasis lymph nodes. Results The expression of DAB2IP in normal mucosae was extremely higher than that in colorectal cancer tissues and metastasis lymph nodes (P ＜ 0.05). The DAB2IP expression in colorectal cancer tissues is related to lymph node metastasis, distant metastasis, LNR (lymph node ratio) , Dukes stage, CEA and survival time (P＜0.05). DAB2IP is an important prognosis factor. Conclusion Down-regulated DAB2IP may result in occurrence, infiltration, metastasis and shorter survival time.%探讨抑癌基因DAB2IP在结直肠癌中的表达及临床意义.方法:采用免疫组织化学方法对103例结直肠癌组织、正常黏膜和转移淋巴结组织进行蛋白检测.结果:DAB2IP在正常黏膜中的表达远高于结直肠癌组织和转移淋巴结组织(P＜0.05),其表达水平与淋巴结转移、远处转移、淋巴结转移度、临床Dukes分期、CEA和生存时间相关(P＜0.05),DAB2IP是结直肠癌重要的预后因素(P＜0.05).结果:DAB2IP下调可能导致结直肠癌的发生、浸润转移和生存时间减少.
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