Objective:To explore the correlation between ACE gene insertion/deletion (I/D) polymorphism and the onset of pregnancy-induced hypertension.Methods:Based on the principles and methods of Cochrane systematic reviews,we searched the PubMed,Cochrane Library,CNKI and VIP databases for studies related to the correlationship between ACE gene insertion/deletion (I/D) polymorphism and the onset of pregnancy-induced hypertension from the date of database inception to 1 st september 2016.inclusion and exclusion criteria for the choosing of the literatures were confirmed.Meta analysis was conducted calculated by Revman5.t.When the data was dichotomous,the pooled value of the odds ratios(OR) and 95％ confidence interval(CI) were calculated.Results:63 studies were identified for in the meta analysis,including 42 studies to Asians population,20 toC aucasians population and one to Africans population,and including 12030 cases of pregnancy-induced hypertension(study group),and 14090 cases of controls(control group).Meta analysis results indicated that in overall populations,in Asians and in Caucasian population,there were differences on the distribution of D allele,DD allele and Ⅱ genotype between study group and control group,the ORs for D allele were 1.42,1.47,1.34,P＜0.00001,P=0.0004,P ＜0.0001;the ORs for DD genotype were 1.62,1.67,1.56,P ＜ 0.00001,P =0.0007,P ＜ 0.00001;the ORs for Ⅱ genotype were 0.72,0.68,0.81,P =0.0003,P=0.002,P=0.10.Conclusions:ACE D allele and DD genotype are closely related to the onset of pregnancy-induced hypertension.In the overall populations and Asians population,Ⅱ genotype is the protect factor for the onset of pregnancy-induced hypertension,but inCaucasian population,no such correlation is found.%目的:探讨不同人群中血管紧张素Ⅰ转换酶(ACE)基因插入(Ⅰ)/缺失(D)多态性与妊娠期高血压疾病发病的关系.方法:检索PubMed、Cochrane、清华同方、重庆维普,时间从该数据库建立至2016年10月1日.全面收集有关妊娠期高血压疾病发病与ACE I/D基因多态性相关的研究文献,制定文献纳入及排除标准.应用Revman 5.1软件进行Meta分析,计数资料采用优势比(OR)及其95％ CI表示.结果:纳入63篇符合条件的研究文献,其中42篇是对亚洲人群的研究,20篇是对欧洲人群的研究,l篇是非洲人群的研究,共纳入妊娠期高血压疾病患者12030例(病例组),健康正常人群14090例(对照组).Meta分析结果显示,在总体人群、亚洲人群和欧洲人群中,D等位基因、DD基因型以及Ⅱ基因型在病例组和对照组分布的差异性,D等位基因OR分别为1.42、1.47、1.34,P＜0.00001、P=0.0004、P＜0.0001;DD基因型OR分别为1.62、1.67、1.56,P＜0.00001、P=0.0007、P＜0.00001;Ⅱ基因型OR分别为0.72、0.68、0.81,P=0.0003、P=0.002、P=0.10.结论:ACE D等位基因和DD基因型同妊娠期高血压疾病发病关系密切.在总体人群和亚洲人群中,Ⅱ基因型是妊娠期高血压疾病发病的一种保护性因素;而欧洲人群未发现有关系.
展开▼
