Objective:To assess the clinical efficacy of two different diameter Osstem MS one-stage implant restoration of small edentu-lous space in the mandibular anterior region.Methods:85 patients were treated by Osstem MS one-stage implant with the diameter of 2.5 mm(n =66)and 3.0 mm(n =66)respectively for the restoration of small edentulous space in mandibular anterior region.The mesi-al and distal marginal bone level and soft tissue were statistically analyzed after 1 2 and 24 months of functional load.The implant survival rate was evaluated according to Wheeler's survival criteria.Results:The survival rate of the implants was 1 00%.The mean changes in marginal bone level(mm)on the mesial side of 2.5 mm and 3.0 mm diameter implants were 0.275 ±0.638 and 0.098 ±0.31 9,distal aspects were 0.360 ±0.588 and 0.1 09 ±0.323 after 1 2 months of functional load;while 0.299 ±0.672 and 0.099 ±0.31 8,0.381 ± 0.581 and 0.1 07 ±0.31 9 after 24 months of functional load.The mesial and distal marginal bone loss of 2.5 mm diameter implant was greater than that of 3.0 mm after 1 2 and 24 months of functional load(P <0.05).No significant change on the marginal bone level was found aomog the same diameter implants from 1 2 to 24 month observation(P >0.05).No relevant complication of peri-implant soft tissue was shown.Conclusion:Favorable clinical effects including function and aesthetics can be achieved by Osstem MS one-stage implant with the diameter of 2.5 mm or 3.0 mm for the restoration of small edentulous space in the mandibular anterior region,however,the mar-ginal bone loss was greater around 2.5 mm diameter implant.%目的：评价2种直径 Osstem MS 一段式种植体用于下前牙小间隙种植修复的临床效果。方法：回顾性研究对85名下前牙缺失患者行直径2．5 mm 和3．0 mm 2种 Osstem MS 一段式种植体种植修复的临床效果。观察分析种植体功能负载12个月和24个月时种植体近、远中边缘骨高度变化和周围软组织情况。采用 Wheeler 存留标准评估种植体存留率。结果：85例患者132枚 Osstem MS 一段式种植体存留率为100％；直径2．5 mm（n ＝66）和3．0 mm（n ＝66）种植体功能负载12个月后近中边缘骨高度（mm）变化分别为0．275±0．638和0．098±0．319，远中边缘骨高度变化分别为0．360±0．588和0．109±0．323；24个月后近中分别为0．299±0．672和0．099±0．318，远中分别为0．381±0．581和0．107±0．319；3．0 mm 相对2．5 mm 直径种植体在功能负载12个月和24个月后近远中边缘骨吸收程度较小（P ＜0．05），同一直径种植体植入后12个月和24个月边缘骨高度变化不明显（P ＞0．05）。未发现种植体周围相关软组织并发症。结论：Osstem MS 一段式种植体用于下前牙小间隙种植修复均可以取得功能和美学上良好的临床效果，直径3．0 mm 较2．5 mm 种植体边缘骨吸收程度更小。
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