Objective:To investigate the expression of Slug,EMMPRIN and E-cadherin in salivary adenoid cystic carcinoma (SACC)and its correlation with clinicopathological characteristics,and the correlation among themselves.Methods:Slug,EMMPRIN and E-cadherin expression in 1 1 5 SACC cases of SACC was examined by immunohistochemical staining.The results and clinicopatho-logical data were statistically analyzed.Results:High positive expression frequencies of Slug(76.5%)and EMMPRIN(69.6%)and low positive expression frequency of E-cadherin(51 .3%)were found in 1 1 5 SACC cases.The expression of Slug and EMMPRIN was positively associated with the histopathological types,clinical stages,perineural invasion,recurrence and distance metastasis(P <0.05).The expression of E-cadherin was negatively associated with the histopathological types,clinical stages,perineural invasion and distance metastasis(P <0.05).There was a significant correlation between Slug and EMMPRIN expression(P <0.05),negative correlation between EMMPRIN and E-cadherin expression(P <0.05)and between Slug and E-cadherin expression(P <0.05).Con-clusion:The expression of Slug,EMMPRIN and E-cadherin is closely correlated to the clinicopathological characteristics of SACC.%目的：研究 Slug、EMMPRIN 和 E-cadherin 在唾液腺腺样囊性癌（salivary adenoid cystic carcinoma，SACC）中的表达情况与临床病理特征间的关系及三者表达的相关性。方法：免疫组织化学染色方法检测115例 SACC 组织中 Slug、EMMPRIN 和E-cadherin 的表达情况，结合临床病理资料进行统计学分析。结果：115例 SACC 标本中 Slug 和 EMMPRIN 阳性表达率分别为76．5％和69．6％，E-cadherin 阳性表达率为51．3％。Slug 和 EMMPRIN 的表达与 SACC 肿瘤病理分型、临床分期、神经侵袭、复发、远处转移呈显著相关（P ＜0．05），E-cadherin 的表达与肿瘤病理分型、临床分期、神经侵袭、远处转移呈显著负相关（P ＜0．05）。同时，Slug 的表达与 EMMPRIN 的表达呈显著正相关（P ＜0．05）；EMMPRIN、Slug 的表达与 E-cadherin 的表达均呈显著的负相关（P ＜0．05）。结论：Slug、EMMPRIN 和 E-cadherin 在 SACC 中的表达与 SACC 的临床病理特征密切相关。
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