Objective:To observe the efficacy and safety of compound danshen dripping pills(DDP)combined with intralesional tri-amcinolone acetonide(TA)injection in the treatment of oral submucous fibrosis(OSF).Methods:34 patients with clinically con-firmed OSF were randomly divided into 2 groups(n =17)and treated with DDP +TA and TA respectively,meanwhile the VAS of pain and mouth opening were recorded and compared.Results:Before treatment there was no statistical difference of the VAS scores and mouth opening between 2 groups(P >0.05),12 weeks after treatment,the difference was significant(P <0.05).The clinical condi-tion of treatment group were improved(χ2 =6.051,P <0.05),but there were no improvement in control group(χ2 =3.429,P >0.05).Conclusion:Compound danshen dripping pills combined with intralesional triamcinolone acetonide injection can significantly enhance the effects safely in the treatment of OSF.%目的：评价复方丹参滴丸联合曲安奈德治疗口腔黏膜下纤维性变的临床疗效。方法：34例口腔黏膜下纤维性变患者随机分为试验组和对照组，分别采用复方丹参滴丸联合曲安奈德及单独曲安奈德治疗，同时记录疼痛 VAS 分值和张口度大小，治疗12周后评价疗效。结果：2组间 VAS 分值和张口度治疗前无差异（P ＞0．05），治疗后差异有统计学意义（P ＜0．05），试验组总体病情改善（χ2＝6．051，P ＜0．05），对照组无明显改善（χ2＝3．429，P ＞0．05）。结论：复方丹参滴丸联合曲安奈德治疗口腔黏膜下纤维性变安全有效，优于单独使用曲安奈德局部注射。
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