目的:探讨干扰素调节因子-4(IRF-4)结合蛋白在口腔鳞癌中的表达及意义.方法:用免疫组化检测IRF 4结合蛋白在6例正常口腔黏膜及78例口腔鳞癌组织中的表达情况,分析其表达水平与临床病理指标之间的关系.结果:在78例口腔鳞癌中有36例IRF-4结合蛋白呈阳性表达,而6例口腔正常黏膜组织中未见IRF-4结合蛋白表达.IRF-4结合蛋白的表达与口腔鳞癌大小、TNM分期及是否发生远处转移呈正相关(P＜0.05),而与其分化程度呈负相关(P＜0.05).结论:口腔鳞癌组织中IRF 4结合蛋白的高表达可能与口腔鳞癌的发生、发展相关.%Objective: To investigate the expression of interferon regulatory factor 4 (IRF-4) binding protein in oral squamous cell carcinoma (OSCC) and it's clinical significance. Methods; TIRF-4 binding protein expression was detected by immunohistochemistry with anti-IRF-4 binding protein polyclonal antibodies in 78 cases of primary OSCC cancer tissues and 6 cases of normal oral mucosa epithelium tissues. The relationship between the IRF-4 binding protein expression level and the clinicopathological parameters was analyzed by SPSS 11.0 software package. Results:Positive expression of IRF-4 binding protein was observed in 36 out-off the 78 OSCC cases and none of the normal oral tissues. IRF-4 binding protein expression was positively correlated with tumor size, clinical stage, and distant metastasis(P <0. 05) , but negatively correlated with differentiation(P <0. 05). Conclusion; Up-regulation of IRF-4 binding protein expression may be related to the tumorigenesis and development of OSCC.
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