Objective: To investigate the relationship between DNA ploidy, synthesis phase fraction(SPF) and tongue squamous cell carcinoma with different pattern of invasion. Methods; 43 cases with histologically proven tongue squamous cell carcinoma were classified into four groups accrording to the pattern of invasion described by Anneroth. DNA ploidy and SPF were examined by Flow cytome-try. Results; DNA ploidy and SPF in the tumor cells were varied with the invasion pattern. With the pattern of invasion development, the incidence of aneuploid tumor and the SPF gradually increased(P <0. 05). Conclusion; DNA ploidy and SPF can be considered to be one of effective factors for evaluating the malignance grading of tongue cancer.%目的:探讨舌癌不同浸润方式与其DNA倍体及合成相分数(SPF)的关系.方法:按Anneroth等介绍的方法将43例病理确诊为舌癌的存档蜡块分为4型不同浸润方式,用流式细胞术(FCM)检测舌癌不同浸润方式DNA倍体及细胞周期中S期细胞比例(SPF).结果:DNA倍体类型及SPF与肿瘤的浸润方式有关,随着浸润分型的发展,异倍体肿瘤细胞的检出率、SPF逐渐上升.结论:DNA倍体类型及SPF可作为舌癌恶性程度的有效指标之一,为临床治疗方案设计提供依据.
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