Objective: To explore the effect of lifestyle intervention on patients with bipolar disorder complicated with metabolic syndrome, and to provide reference for early intervention and prevention measures. Methods: A total of 62 patients with bipolar disorder complicated with metabolic syndrome were randomly divided into intervention group and control group, 31 cases in each group. The intervention group was given lifestyle intervention for 3 months, while the control group was given routine nursing and education. The quality of life was assessed by World Health Organization Quality of Life (WHOQOL-BREF) at the time of admission and at the end of the third month. The waist circumference, blood pressure, fasting blood sugar and blood lipid levels were compared between the two groups. Results: At the end of the third month, the waist circumference, fasting blood sugar, systolic blood pressure, diastolic blood pressure, blood cholesterol and triglyceride levels in the intervention group were significantly lower than those in the control group (P < 0.05) , and the intervention group was lower than those in the control group at the same time (P < 0.05). At the end of the third month, the total score of WHOQOL-BREF in the intervention group was significantly higher than that at the time of admission (P < 0.01) , and that in the intervention group was higher than that in the control group at the same time (P < 0.01). Conclusion: Lifestyle intervention can effectively improve the metabolic indicators of patients with bipolar disorder and metabolic syndrome, and improve the quality of life of patients, which is worthy of clinical promotion.%目的:探讨生活方式干预对双相障碍合并代谢综合征患者的影响, 为早期干预和防治措施提供参考.方法:将住院及门诊诊断为双相障碍合并代谢综合征的62例患者随机分为干预组和对照组各31例, 干预组实施生活方式干预, 干预时间为3个月, 对照组实施常规护理和教育;两组在入组时和第3个月末均采用世界卫生组织生存质量测定简表 (WHOQOL-BREF) 评估生存质量, 比较两组腰围、血压、空腹血糖、血脂水平.结果:干预第3个月末, 干预组腰围、空腹血糖、收缩压、舒张压、血胆固醇以及甘油三酯水平明显低于入组时 (P <0.05) , 且干预组低于对照组同期 (P <0.05) ;干预第3个月末, 干预组WHOQOL-BREF总分明显高于入组时 (P <0.01) , 且干预组高于对照组同期 (P <0.01) .结论:生活方式干预可有效改善双相障碍合并代谢综合征患者的代谢指标, 提高患者生存质量, 值得临床推广.
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