Objective: To study the effect of endometrial preparation with constant low dose 17 β estradiol in recipients of oocyte donation program.rn Methods: 43 recipients suffering from infertility due to ovarian failure or chromosome abnormality were treated with micronized 17 β estradiol (estrofem) and oocyte donation from lst January 1999 to 31 st July 2000. The donors included 40 infertile women in the assisted reproductive technology program and 5 normal women.rn Results: Clinical pregnancy rate were 39% in recipients and 36% in donors respectively (P>0.05). There was no significant difference in the mean age, causes of infertility and the number of embryos transferred between pregnant and non-pregnant groups for both recipients and donors.rn Conclusion: Preparation of endometrum for recipients with estrofem 1～2 mg/d is an effective method in oocyte donation program.%目的：研究恒定、低剂量微粒化17 β雌二醇(诺坤复)在赠卵助孕术中的应用。方法：1999年1月至2000年7月，应用诺坤复1～2 mg/d和黄体酮为43例接受赠卵的患者准备子宫内膜共51个周期，由40例同期行体外受精和胚胎移植(IVF-ET)或配子输卵管内移植术(GIFT)的不孕患者和5名正常妇女提供卵母细胞。结果：供卵和接受赠卵者共移植90个周期，妊娠34例，妊娠率为38%。接受赠卵的51个周期中，临床妊娠20例，供卵者移植39例中，临床妊娠14例，妊娠率分别为39%和36%，两组间无显著差别，妊娠与未妊娠患者之间平均年龄、不孕原因和移植的胚胎数等均无显著差别。结论：在等待赠卵期间，用低剂量(1～2 mg/d)诺坤复可有效地刺激子宫内膜生长，为胚胎移植作准备。
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