Evacuation and shelter-in-place has usually been used to protect public from toxic gas release incidents. When evacuation is noneffective, shelter-in-place should be considered. So emergency decision-makers should have an accurate understanding on the reliability of shelter-in-place. Effects of sink adsorption, air exchange rate, safe-room volume and effective adsorption area on safe-room concentration were studied in this paper. It showed that the existence of adsorption significantly reduced the indoor concentration, and the greater the intensity was, the lower concentration was; the smaller the air exchange rate was, the lower concentration was; the larger the safe-room volume was, the lower concentration was, but the effect was not obvious; the larger the absorption area and space volume ratio were, the concentration declined more obvious; the greater the toxic load index was, the lower toxic load increased in shelter-in-place in stated exposure time. Finally, the optimal air exchange rate was determined in a specific scenario. This study will be helpful for guiding the selection and design of emergency shelters.%有毒气体泄漏时,疏散和就地避难都是保护人员安全的有效行动.当疏散行动无效时,此时可考虑进行就地避难,应急决策者必须准确认识就地避难的可靠性.文中模拟分析了渗透吸附作用、换气次数、避难室空间体积、有效吸附面积对避难室内浓度的影响.结果表明,渗透吸附作用的存在明显降低了室内浓度,且强度越大浓度越低；换气次数越小,浓度越低；避难室空间越大,浓度越低,但影响不明显；吸附面积与空间体积之比越大,浓度下降越明显；毒负荷指数越大,规定暴露时间内避难室内毒负荷上升越缓慢.最后确定了特定场景下避难室最佳换气次数.
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