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首页> 中文期刊> 《上海交通大学学报：医学英文版》 >STUDY ON THE RELATIONSHIP BETWEEN PARAOXONASE GENE POLYMORPHISM AND CORONARY ARTERIAL DISEASE IN NIDDM

STUDY ON THE RELATIONSHIP BETWEEN PARAOXONASE GENE POLYMORPHISM AND CORONARY ARTERIAL DISEASE IN NIDDM

         
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摘要

Objective To ascertain the relationship between paraoxonase gene (PON) and the morbidity of coronary arterial disease (CAD) in Chinese non-insulin-dependent diabetes mellitus (NIDDM) patients. Methods The exons of PON gene were screened by polymerase chain reaction-denaturing gradient gel electrophoresis in 49 NIDDM patients complicated with CAD, 49 NIDDM and 101 healthy control cases of Chinese population. Results Gln-Arg191 polymorphism of the PON gene was detected in Chinese with the A/B allele frequency 0.39 and 0.61 respectively. The genotype distribution (AA, AB and BB) of the PON gene polyrnorphism was significantly different between NIDDM patients complicated with CAD and controls (NIDDM and healthy subjects). The former had a significantly higher B allele frequency (0.79 vs 0.62 and 0.61, P <0.01 ). Conclusion Gln-Arg191 polymorphisrn of the PON gene is associated with CAD morbidity in Chinese NIDDM patients and B allele might be a risk factor.

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