Objective To get a thorough understanding about the distribution and dynamic changes of the glutathione peroxidase (GPx) activity in pigs.[Method] Using three varieties of pigs as the subject , GPx activities of different tissues and whole blood from pig with different species , genders , age periods and health statuses were determined in this study .[Result and conclusion] The result showed that the GPx activity of whole blood from Lantang or Landrace pigs was slowly rising from 26 to 150 d, reaching a maximum at 150 d.The GPx activity of Lantang pigs was significantly higher than that of Landrace pigs during the periods of 30 and 90 d(P<0.05)and no significant difference in the other periods .The GPx activity of hybrid boars ( Duroc ×Yorkshire ×Landrace ) was significantly higher than that of sows ( P<0.05 ); the GPx activity of healthy pigs ( Duroc ×Yorkshire ×Landrace ) was significantly higher than that of sick ones(P<0.05).Samples from different tissues revealed that kidney , spleen, liver, lung, heart and ileum showed a higher Gpx activity and these tissues can be used as ideal raw materials for ex -tracting GPx.%【目的】全面了解谷胱甘肽过氧化物酶（ GPx）在猪体内的分布和动态变化．【方法】以3个品种的猪为研究对象，测定了不同组织中及不同品种、性别、龄期、健康状态猪血液中的GPx活力．【结果和结论】在26～150日龄，长白猪和蓝塘猪全血中的GPx活力随着龄期的增加而缓慢上升，至150日龄时达到最大值；蓝塘猪各龄期GPx活力高于长白猪GPx活力，30和90日龄GPx活力显著高于长白猪的GPx活力（ P＜0.05）；90日龄杜大长公猪GPx活力显著高于母猪的GPx活力（P＜0.01）；90日龄健康杜大长猪GPx活力显著高于病猪的GPx活力（P＜0.01）．对不同组织GPx活力和比活力进行比较，结果发现猪的肾、脾、肝、肺、心和回肠等组织的活力和比活力较高，可作为理想的提取GPx的原材料．
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