Fourteen healthy pigs were divided into two groups of 7 pigs each. The pigs in group A were o-rally administrated with single dose of florfenicol powder at 30 mg/kg. The pigs in group B were also orally administrated with single dose of florfenicol granule at 30 nig/kg. Comparative study on the pharmaco-kinetics of florfenicol powder and florfenicol granule was carried out. Plasma concentration of florfenicol was determined by HPLC. The concentration-time data of florfenicol were analyzed by non-compartmental model based on pharmacokinetic software WinNonlin 5.2. 1. The main pharmacokinetic parameters of powder following oral administration were :f,/2p = (10. 22±0.18) h, k, = ( 0. 07 ± 0. 01) h -1, tmax= (1.67 ±0.48) h, Cmax = (24.68 ±1.13) μg · mL-1, AUC = (190.97 ±16.60) μg · mL-1 · H, MRT = (8. 33 ±0. 42) h, tcp = (17. 66 ± 1. 52) h. The main pharmacokinetic parameters of granule following oral administration were :t1/2β= (16. 36 ±4. 14) h,ke = (0. 05 ±0. 01) h-', tmax = (5.71 ± 0.47) h, Cmax = (12.23 ±0.78) μg · mL-1, AUC = (155.44 ±6. 59) mg · mL-1 · H, MRT = (14. 96 ± 0. 35) h, tcp = ( 23. 03 ± 0. 49) h. The results showed the granule of florfenicol after oral administration had slower elimination and longer effective time of the blood medicine density maintenance.%健康猪14头随机分为A、B2组,分别单剂量胃管灌服氟苯尼考粉和颗粒,按体质量给药剂量均为30 mg/kg,进行比较药动学研究.高效液相色谱法(HPLC)测定其血药浓度.采用药动学分析软件WinNonlin5.2.1的非房室模型处理血药浓度-时间数据.氟苯尼考粉灌胃给药的主要药物动力学参数为:t1/2β=(10.22±0.18)h,ke=(0.07±0.01)h-1,tmax =(1.67±0.48)h,Cmax=(24.68±1.13)μg·mL-1,AUC=(190.97±16.60)μg·mL-1·h,MRT=(8.33±0.42)h,tcp=(17.66士1.52)h.氟苯尼考颗粒灌胃给药的主要药物动力学参数为:t/2β=(16.36±4.14)h,κe=(0.05±0.01)h-1,tmax=(5.71±0.47)h,Cmax=(12.23±0.78)μg·mL-1,AUC=(155.44±6.59)μg·mL-1·h,MRT=(14.96±0.35)h,tep=(23.03±0.49)h.试验结果表明,与氟苯尼考粉相比,氟苯尼考颗粒的消除半衰期更长,有效血药浓度维持时间也较长.
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