Construction of Multilayer Porous Scaffold Based on Magnetically Guided Assembly of Microfiber

LI Xingfu; WANG Huaping; SHI Qing; SUN Tao; HUANG Qiang; FUKUDA Toshio

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Construction of Multilayer Porous Scaffold Based on Magnetically Guided Assembly of Microfiber

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This paper proposes a novel method of magnetically guided assembly to construct multilayer porous scaffold for three-dimensional cell culture by apply magnetic microfibers.Microfibers are composed of biocompatible and biodegradable alginate solution with homogeneous magnetic nanoparticles,which are continuously spun from a microfluidic device by precise pressure control of the syringe pump.Magnetic nanoparticles enable the control of magnetic field on microfibers.Meanwhile,magnetized device combining with a round permanent magnet are utilized to guide the distribution of spouted microfibers.The device is composed by pure iron wire arrays and wax,which stimulates powerful magnetic flux density and magnetic field gradients for the capture and assembly of microfibers.Thus,magnetic microfibers are spun on desired places of the magnetized device by motion control of the micromanipulation robot,and precise locations are adjusted by magnetic force couple with the assist of glass micropipette.Afterwards,microfibers are spatially organized by periodic magnetic force and crossed layer-by-layer to form micro-pore structure with both length and width of 650 μm.Finally,the authors construct a multilayer microfiber-based scaffold with high porosity to provide a satisfactory environment for long-term cell culture.The experimental results demonstrate the effectiveness of the proposed method.

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《系统科学与复杂性：英文版》 |2018年第3期|581-595|共15页
作者
LI Xingfu; WANG Huaping; SHI Qing; SUN Tao; HUANG Qiang; FUKUDA Toshio;
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Intelligent Robotics Institute,School of Mechatronical Engineering,Beijing Institute of Technology,Beijing 100081,China;

Key Laboratory of Biomimetic Robots and Systems,Ministry of Education,Beijing 100816,China;

Key Laboratory of Intelligent Control and Decision of Complex Systems,Beijing 100081,China;

Intelligent Robotics Institute,School of Mechatronical Engineering,Beijing Institute of Technology,Beijing 100081,China;

Key Laboratory of Biomimetic Robots and Systems,Ministry of Education,Beijing 100816,China;

Key Laboratory of Intelligent Control and Decision of Complex Systems,Beijing 100081,China;

Intelligent Robotics Institute,School of Mechatronical Engineering,Beijing Institute of Technology,Beijing 100081,China;

Key Laboratory of Biomimetic Robots and Systems,Ministry of Education,Beijing 100816,China;

Key Laboratory of Intelligent Control and Decision of Complex Systems,Beijing 100081,China;

Intelligent Robotics Institute,School of Mechatronical Engineering,Beijing Institute of Technology,Beijing 100081,China;

Key Laboratory of Biomimetic Robots and Systems,Ministry of Education,Beijing 100816,China;

Key Laboratory of Intelligent Control and Decision of Complex Systems,Beijing 100081,China;

Intelligent Robotics Institute,School of Mechatronical Engineering,Beijing Institute of Technology,Beijing 100081,China;

Key Laboratory of Biomimetic Robots and Systems,Ministry of Education,Beijing 100816,China;

Key Laboratory of Intelligent Control and Decision of Complex Systems,Beijing 100081,China;

Intelligent Robotics Institute,School of Mechatronical Engineering,Beijing Institute of Technology,Beijing 100081,China;

Key Laboratory of Biomimetic Robots and Systems,Ministry of Education,Beijing 100816,China;

Key Laboratory of Intelligent Control and Decision of Complex Systems,Beijing 100081,China;

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Construction of Multilayer Porous Scaffold Based on Magnetically Guided Assembly of Microfiber

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