AIM: To compare and observe the clinical efficacy of gabapentin and carbamazepine in the treatment of recurrent trigeminal neuralgia. METHODS: A total of 76 patients with recurrence of trigeminal neuralgia in our hospital were selected and randomly divided into carbamazepine group and gabapentin group. Patients in carbamazepine group were treated by carbamaz⁃epine, and those in gabapentin group were treated by gabapentin. Clinical curative effect was compared between the two groups. RESULTS: Dosage of carbamazepine was less than that of gabapentin, and the difference was statistically significant ( P<0.05) . VAS of 1, 2 and 4 weeks after treatment in the two groups were significantly higher than that before treatment, and the difference was statistically significant ( P<0. 05 ) . LSI⁃B of the gabapentin group after 4⁃week treatment was higher than that of the carbamazepine group, and LSI⁃B improved in both groups after treatment, with statistically significant difference ( P<0.05) . Besides, incidence of adverse reactions of gabapentin group was lower than that of the gabapentin group, and the difference was statistically significant (P<0.05). CONCLUSION: The clinical curative effect of carbamazepine and gabapentin in the treatment of recurrent trigeminal neuralgia are almost the same, but gabapentin cause lower incidence of adverse reactions, improves the quality of life of patients more obviously, and is a better choice for the treatment of trigeminal neuralgia.%目的：观察加巴喷丁与卡马西平治疗复发性三叉神经痛的临床疗效．方法：选取我院收诊的复发性三叉神经痛患者76例，采取数字随机法分成加巴喷丁组和卡马西平组，加巴喷丁组采取加巴喷丁治疗，卡马西平组采取卡马西平治疗，比较两组临床疗效．结果：卡马西平组药物用量低于加巴喷丁组，差异有统计学意义（P＜0．05）．两组治疗后1、2、4周VAS评分均高于治疗前，差异有统计学意义（P＜0．05）．加巴喷丁组治疗4周后LSI⁃B高于卡马西平组，且两组治疗4周后LSI⁃B均优于治疗前，差异有统计学意义（ P＜0．05）．加巴喷丁组不良反应发生率低于卡马西平组，差异有统计学意义（P＜0．05）．结论：卡马西平以及加巴喷丁治疗复发性三叉神经痛的临床疗效相当，但加巴喷丁的不良反应发生率更低，对患者生活质量改善作用更加明显，是治疗三叉神经痛的更佳选择．
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