EFFECTS OF CHRONIC STRESS ON THE ACTIVITIES OF SOD, GSH-Px AND MDA LEVEL IN FEMALE RATS' BRAIN

Wang; Ying(王莹); Yang; Dongwei(杨东伟); Xie; Wen(谢雯); Pang; Wei(庞炜); Jiang; Mali(蒋马莉); Han; Taizhen(韩太真)

首页> 中文期刊> 《西安交通大学学报：英文版》 >EFFECTS OF CHRONIC STRESS ON THE ACTIVITIES OF SOD, GSH-Px AND MDA LEVEL IN FEMALE RATS' BRAIN

EFFECTS OF CHRONIC STRESS ON THE ACTIVITIES OF SOD, GSH-Px AND MDA LEVEL IN FEMALE RATS' BRAIN

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Objective To observe the effects of chronic emotional stress on the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and malonialdehyde (MDA) level in female rats’ brain. Methods The rats were randomly divided into 4 groups: normal control group (group N), emotional stress group (group E), emotional stress + pregnancy group (group E+P) and regularly drinking group (group R). Emotional stress in rats was induced by training rats with empty drinking bottles. Having been finished the stress procedure, the brain was taken out and homogenized. Then the activities of SOD, GSH-Px and MDA level were measured. Results Compared to group N, both the activities of SOD in brain tissues of group E and group E+P were significantly decreased ( P <0.05 and P <0.01, respectively) while the MDA level increased ( P <0.05). However, the extent of changes in group E+P was more obvious than that in E. GSH-Px activities in E+P and E were significantly changed. However, the GSH-Px activity in E+P was decreased ( P <0.05) while the activity in E increased ( P <0.05).Conclusion The chronic emotional stress can reduce the antioxidative system by decreasing the antioxidative enzyme activity and potentiating the lipid peroxidation in the brain. It is also suggested that the combination of emotional stress and pregnancy can augment the oxidative damage in rats’ brain.

著录项

来源
《西安交通大学学报：英文版》 |2002年第2期|144-146|共3页
作者
Wang; Ying(王莹); Yang; Dongwei(杨东伟); Xie; Wen(谢雯); Pang; Wei(庞炜); Jiang; Mali(蒋马莉); Han; Taizhen(韩太真);
展开▼
作者单位

Department of Physiology;

Medical School of Xi''an Jiaotong University;

Xi''an 710061;

China. Department of Physiology;

Medical School of Xi''an Jiaotong University;

Xi''an 710061;

China. Department of Physiology;

Medical School of Xi''an Jiaotong University;

Xi''an 710061;

China. Department of Physiology;

Medical School of Xi''an Jiaotong University;

Xi''an 710061;

China. Department of Physiology;

Medical School of Xi''an Jiaotong University;

Xi''an 710061;

China. Department of Physiology;

Medical School of Xi''an Jiaotong University;

Xi''an 710061;

China.;

展开▼
原文格式 PDF
正文语种 chi
中图分类中枢神经系统生理学;
关键词
chronic; emotional; stress; oxidative; damage; lipid; peroxide; SOD; MDA; GSH-Px;

机译：慢性情绪压力;氧化损伤;脂质过氧化物;SOD;MDA;GSH-PX;

EFFECTS OF CHRONIC STRESS ON THE ACTIVITIES OF SOD, GSH-Px AND MDA LEVEL IN FEMALE RATS' BRAIN

摘要

著录项

相关主题

期刊订阅