Objective To study the relationship between plasma fibrinogenand type 2 diabetic neuropathy. Methods 252 patients with type 2 diabetes mellitus (60 patients with dementia,106 patients with periph-eral neuropathy,42 patients with cranial nerve lesion,44 patients without complications)and 50 cases of healthy people were selected.All subjects were detectedplasma fibrinogen (FIB).To find the factors which affect FIB and intervene the factors,the improvement of diabetic neuropathy were observed.Results The levels of plasma FIB had significant difference among the patients with diabetic neuropathy,diabetes pa-tients without complications and healthy people (F =77.64,114.02,30.84,P <0.01);The FIB of severe diabetic peripheral neuropathy patients was higher than that of mild cases (t = 5.2448,P <0.01).There were no significant difference of FIB of severe cases and mild cases in dementia patients and cranial nerve lesions patients (t = 0.827 3,0.581 2,P > 0.05);Compared with normal FIB patients,the number of smoking and the levels of MPV,PDW indiabetic neuropathypatients in high FIB were significantly higher (t =12.3758,8.671 8,13.191 5,P <0.01).There were no significant difference in TG,TCH,LDL,HDL and HbA1c between the two groups (t =1.052 8,1.024 3,0.819 4,0.740 4,1.511 8,P >0.05).Spearman analysis showed that the levels of FIB was positively correlated with the degrees of diabetic peripheral neu-ropathy (r =0.8743,P <0.01).There were no significant correlation between the levels of FIBand the de-gree of dementia and cranial neuropathy (r =0.4818、0.4394,P >0.10).Conclusion The high level of FIB could be one of factors to worsen the type 2 diabetic neuropathy.Giving up smoking and anti-platelet aggre-gate may delay the disease progression.%目的：探讨纤维蛋白原（FIB）与2型糖尿病神经病变之间的关系。方法选取2型糖尿病患者252例，其中痴呆60例，周围神经病变106例，颅神经病变42例，单纯糖尿病无并发症者44例，另取体检者（健康人群）50例，测定 FIB 水平。寻找影响 FIB 因素，予以干预，观察糖尿病神经病变改善情况。结果糖尿病神经病变（痴呆、外周神经病变、颅神经病变）、单纯糖尿病、健康人群三者间 FIB 差异有统计学意义（F ＝77．64、114．02、30．84，P值均＜0．01）；重度糖尿病外周神经病变血浆 FIB 高于轻度患者（t ＝5．2448，P ＜0．01），而痴呆以及颅神经病变的重度与轻度之间血浆 FIB 无明显差异（t ＝0．8273、0．5812，P ＞0．05）；高 FIB 与正常 FIB 患者相比，吸烟程度、血小板参数（MPV、PDW）等情况有显著的差异性（t ＝12．3758、8．6718、13．1915，P 均＜0．01），而血脂水平（TG、TCH、LDL、HDL）、血糖水平（HbA1c）水平则无明显差异（t ＝1．0528、1．0243、0．8194、0．7404、1．5118，P 均＞0．05）；Spearman 分析显示，FIB 与糖尿病外周神经病变呈正相关（r ＝0．8743，P ＜0．01），而与糖尿病脑老化痴呆和颅神经病变之间无显著相关性（r ＝0．4818、0．4394，P 值均＞0．10）。结论FIB 水平增高是2型糖尿病神经病变的原因之一，戒烟、抗凝治疗有可能延缓病情的进展。
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