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首页> 中文期刊> 《实验动物与比较医学》 >束缚应激致亚健康状态大鼠脑组织Bax、c-Fos的表达及中药干预作用

束缚应激致亚健康状态大鼠脑组织Bax、c-Fos的表达及中药干预作用

         
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目的 观察束缚应激致亚健康模型大鼠的脑组织Bax、c-Fos表达情况以及抗衰老片和六味地黄丸的干预作用.方法 取雄性SD大鼠20只,体重320-360g,随机分成4组,即正常对照组、模型对照组、抗衰老片组、六味地黄丸组,每组5只,采用每天限制活动3 h模拟人类束缚应激,建立大鼠亚健康状态模型,造模同时,用抗衰老片、六味地黄丸进行干预.造模14 d结束后,测定大鼠大脑皮质及海马区Bax和c-Fos的表达.结果 造模14 d后,模型对照组大鼠脑组织皮质、海马区Bax的表达面积显著增加(P<0.05);给予抗衰老片和六味地黄丸后,大鼠大脑皮质及海马区Bax表达量明显减少(P<0.05,P<0.01);模型对照组大鼠脑组织皮质、海马区c-Fos表达量增加;给予抗衰老片和六味地黄丸后,大鼠的大脑皮质及海马区c-Fos表达有不同程度的减少(P<0.05,P<0.01).结论 束缚应激致亚健康状态的大鼠大脑皮层、海马区Bax、c-Fos表达量增加.抗衰老片和六味地黄丸可减少束缚应激致亚健康状态大鼠脑组织Bax、c-Fos的表达,预防和减少应激引起的神经元损伤,从而改善亚健康状态.%Objective To observe the expression of Bax and c-Fos in brain tissue of sub-health state rat model induced by restraint stress, and further to study the effect of the Traditional Chinese Medicine.Methods Twenty male SD rats of 320-360g, were randomly divided into 4 with 5 rats per group:normal control group, model control group, Anti-ageing tablets group and Liuwei Dihuang pills group, 5 rats per group. The sub-health state animal model was established by limiting daily movement for 3 hours consecutive to 14 days according to the circumstance that can result human physiological stress. At the same time, the rats in Anti-ageing tablets group and Liuwei Dihuang pills group were treated with Anti-ageing tablets and Liuwei Dihuang pills. Respectively during the model building period. The expression level of Bax and c-Fos in brain tissues were detected on completion of the model establishment. Results Fourteen days after molding, in model control group,the expression level of Bax and c-Fos in cerebral cortex and in hippocampus was increased remarkably, while expression of Bax and c-Fos in anti-aging tablets and Liuwei Dihuang pills treated groups was decreased significantly (P＜0.05,P＜0.01). Conclusion The rat with mental stress were induced by activity restriction have got the expression of Bax and c-Fos significantly increased in brain tissue . The treatments of anti-aging tablets and Liuweidihuang pills improve this kind of mental stress through reducing the expression of Bax and c-Fos, protecting and decreasing neuron injuries caused by stressors.

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