目的：探讨急性心肌梗死（ AMI）患者血清脂联素（ APN）检测的临床意义。方法选择AMI患者、不稳定型心绞痛（UAP）患者、稳定型心绞痛（SAP）患者各40例，以40名健康体检者作为正常对照组，比较各组血清高敏C反应蛋白（hs－CRP）、心肌肌钙蛋白I（cTnI）及APN水平；根据APN中位数将AMI患者分为高APN组和低APN组，比较2组主要心血管事件发生情况。结果正常对照组、SAP组、UAP组和AMI组血清APN水平依次降低，hs－CRP和cTnI依次升高，各组间差异均有统计学意义（ P均＜0．05）。 AMI组APN水平与hs－CRP、cTnI水平均呈明显负相关（r值分别为－0．599、－0．527， P均＜0．05）；随访12个月，低APN组AMI患者主要心血管事件发生率明显高于高APN组（P＜0．05）。结论血清APN水平可能与AMI的发生、发展有关。监测血清APN水平对AMI诊治及预后判断具有一定的临床意义。%Objective To investigate the clinical significance of detecting serum adiponectin ( APN) in patients with acute myocardial infarction (AMI).Methods A total of 40 patients with AMI, 40 patients with unstable angina pectoris (UAP), 40 patients with stable angina pectoris (SAP) and 40 healthy subjects were enrolled in this study . Serum high-sensitivity C reactive protein ( hs-CRP ) , cardiac troponin I ( cTnI ) and APN levels were determined and compared in all patients and healthy subjects .The AMI patients were classified into high APN group and low APN group according to the median of APN levels , and the occurrence of major cardiovascular events were compared between the 2 groups.Results Serum levels of APN decreased in turn among healthy subjects and patients with SAP , UAP and AMI. The levels of hs-CRP and cTnI sequentially increased in these subjects .Correlation analysis showed that APN in AMI patients was negatively correlated with hs-CRP and cTnI ( r =-0.599 and -0.527, P <0.05).The major cardiovascular events in low APN group were significantly more than those in high APN group in the follow -up 12 months (P<0.05).Conclusions Serum APN levels in patients with AMI may be associated with the occurrence and development of AMI.Thus, the monitoring of serum APN levels in AMI patients has clinical significance for the diagnosis , treatment and prognosis of AMI .
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