Objective To investigate the application significance of coagulation factorⅤandⅧactivities (FⅤ:C and Ⅷ:C)and tissue factor(TF)in diagnosis of type 2 diabetes mellitus (T2DM)combined with coronary heart disease (CHD).Methods FⅤ:C,FⅧ:C,TF,von Willibrand factor(VWF)activity and platelet aggregation rate(PAR) were measured in 85 patients with T2DM combined with CHD [T2DM with CHD group,including T2DM with acute myocardial infarction (AMI)group (1 9 cases),T2DMwith old myocardial infarction (OMI)group (23 cases),T2DM with unstable angina pectoris (UAP)group (25 cases)and T2DM with stable angina pectoris (SAP)group (1 8 cases)],29 T2DM patients without complication (single T2DM group)and 24 healthy controls (control group).The correlation between FⅤ:C,FⅧ:C and TF with VWF and PAR was analyzed.Results The levels of FⅤ:C,FⅧ:C and TF in T2DM with CHD group and single T2DM group were remarkably higher than those in control group (P<0.001 ),and those in T2DM with CHD group were higher than those in single T2DM group(P<0.01 ).In T2DM with AMI group and T2DM with UAP group,the levels of FⅤ:C,FⅧ:C and TF were markedly higher than those in single T2DM group(P<0.001 ),and those in T2DM with AMI group were higher than those in T2DM with UAP group(P<0.01 ).In T2DMwith OMI group and T2DMwith SAP group,the TF levels were significantly higher than those in single T2DM group(P<0.01 ),but there was no statistical significance among the 3 groups for FⅤ:C and FⅧ:C levels(P>0.05).There was a significantly positive correlation of FⅤ:C,FⅧ:C and TF levels with VWF and PAR levels(P<0.01 ).Conclusions FⅤ:C,FⅧ:C and TF can be as the indicators for T2DM with CHD.TF is useful for the evaluation of disease development in patients with T2DM with CHD.%目的：探讨凝血因子Ⅴ活性（FⅤ：C）、凝血因子Ⅷ活性（FⅧ：C）和组织因子（TF）在2型糖尿病（T2DM）合并冠心病（HD）诊断中的应用价值。方法测定85例T2DM合并CHD患者[T2DM合并CHD组，根据CHD不同类型再分为T2DM合并急性心肌梗死（AMI）组（19例）、T2DM合并陈旧性心肌梗死（OMI）组（23例）、T2DM合并不稳定型心绞痛（UAP）组（25例）、T2DM合并稳定型心绞痛（SAP）组（18例）]、29例无合并症的单纯T2DM患者（单纯T2DM组）和24名健康对照者（正常对照组）FⅤ：C、FⅧ：C、血浆TF和血管性血友病因子（VWF）活性及血小板聚集率（PAR），并分析FⅤ：C、FⅧ：C、TF与VWF、PAR的相关性。结果 T2DM合并CHD组和单纯T2DM组FⅤ：C、FⅧ：C和TF水平均明显高于正常对照组（P＜0．001），且T2DM合并CHD组明显高于单纯T2DM组（P＜0．01）。T2DM合并CHD组中，T2DM合并AMI组和T2DM合并UAP组FⅤ：C、FⅧ：C和TF水平均明显高于单纯 T2DM组（P＜0．001），且 T2DM合并 AMI 组明显高于 T2DM合并 UAP 组（P＜0．01）；T2DM合并OMI组和T2DM合并SAP组TF水平明显高于单纯T2DM组（P＜0．01），但FⅤ：C和FⅧ：C水平3组之间差异无统计学意义（P＞0．05）。FⅤ：C、FⅧ：C、TF与VWF、PAR均呈明显正相关（P＜0．01）。结论 FⅤ：C和FⅧ：C及TF水平可作为T2DM患者并发CHD的诊断指标。TF对判断T2DM合并CHD患者病情的进展有重要价值。
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