目的 探讨血清可溶性转铁蛋白受体(sTfR)在缺铁性贫血(IDA)诊断中的临床应用价值.方法 选择正常对照组和IDA患者组各58例,同等条件下对2组sTfR、血清铁(Fe)、总铁结合力(TIBC)、转铁蛋白饱和度(TS)、转铁蛋白(Tf)、血清铁蛋白(SF)、血红蛋白(Hb)、平均红细胞容积(MCV)、平均红细胞血红蛋白量(MCH)、平均红细胞血红蛋白浓度(MCHC)、红细胞体积分布宽度(RDW)等指标进行定量检测,并分别行t检验和ROC曲线分析.结果 IDA组血清sTfR浓度为(46.40±9.43) nmol/L,正常对照组的sTfR浓度为(15.45±2.95)nmol/L,与对照组比较,IDA组血清sTfR明显升高,差异具有统计学意义(P＜0.01).用于IDA诊断时,sTfR的R0C曲线下面积达0.971(P＜0.01).结论 血清sTfR浓度可较准确反映铁贮存状况,对IDA的诊断具有一定的临床实用价值.%Objective To investigate the clinical application significance of serum soluble transferrin receptor (sTfR) in diagnosis of iron deficiency anemia (IDA). Methods A total of 58 controls and 58 patients with IDA were enrolled in the study. Iron metabolism related indices such as sTfR, serum iron( Fe) , total iron binding capacity (TIBC), transferrin saturation (TS), transferrin (TF), serum ferritin (SF) , hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) , mean corpuscular hemoglobin concentration (MCHC) and red blood cell volume distribution width ( RDW) were detected quantitatively. The data were analyzed by t test between groups and receiver operating characteristic ( ROC) curve. Results The levels of sTfR were (46.40 ± 9.43) nmol/L in IDA group and (15. 45 ±2. 95) nmol/L in control group. There were statistical significances between the sTfR levels of IDA and control groups (P < 0.01). The area under the ROC curve of sTiR was 0. 971 (P <0.01). Conclusions Serum sTfR can reflect iron storage in body correctly. The sTfR has a clinical application significance in the diagnosis of IDA.
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