Localization optoacoustic tomography

X Luís Dean-Ben; Daniel Razansky

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Localization optoacoustic tomography

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Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues.Herein,we introduce a new concept of localization optoacoustic tomography(LOT)that employs rapid sequential acquisition of three-dimensional optoacoustic images from flowing absorbing particles.We show that the new method enables breaking through the spatial resolution barrier of acoustic diffraction while further enhancing the visibility of structures under limited-view tomographic conditions.Given the intrinsic sensitivity of optoacoustics to multiple hemodynamic and oxygenation parameters,LOT may enable a new level of performance in studying functional and anatomical alterations of microcirculation.

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《光：科学与应用（英文版）》 |2018年第1期|1058-1062|共5页
作者
X Luís Dean-Ben; Daniel Razansky;
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作者单位

Institute for Biological and Medical Imaging;

Helmholtz Center Munich;

Neuherberg 85764;

Germany;

School of Medicine and School of Bioengineering;

Technical University of Munich;

Munich 81675;

Germany;

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原文格式 PDF
正文语种 chi
中图分类光学;
关键词
acoustic diffraction; limited-view effects; localization; optoacoustic imaging; photoacoustic imaging; super-resolution;

Localization optoacoustic tomography

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