Transmission-reflection optoacoustic ultrasound(TROPUS)computed tomography of small animals

Elena Mercep; Joaquin LHerraiz; Xose Luis Dean-Ben; Daniel Razansky

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Transmission-reflection optoacoustic ultrasound(TROPUS)computed tomography of small animals

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Rapid progress in the development of multispectral optoacoustic tomography techniques has enabled unprecedented insights into biological dynamics and molecular processes in vivo and noninvasively at penetration and spatiotemporal scales not covered by modern optical microscopy methods.Ultrasound imaging provides highly complementary information on elastic and functional tissue properties and further aids in enhancing optoacoustic image quality.We devised the first hybrid transmission–reflection optoacoustic ultrasound(TROPUS)small animal imaging platform that combines optoacoustic tomography with both reflection-and transmission-mode ultrasound computed tomography.The system features full-view cross-sectional tomographic imaging geometry for concomitant noninvasive mapping of the absorbed optical energy,acoustic reflectivity,speed of sound,and acoustic attenuation in whole live mice with submillimeter resolution and unrivaled image quality.Graphics-processing unit(GPU)-based algorithms employing spatial compounding and bent-ray-tracing iterative reconstruction were further developed to attain real-time rendering of ultrasound tomography images in the full-ring acquisition geometry.In vivo mouse imaging experiments revealed fine details on the organ parenchyma,vascularization,tissue reflectivity,density,and stiffness.We further used the speed of sound maps retrieved by the transmission ultrasound tomography to improve optoacoustic reconstructions via two-compartment modeling.The newly developed synergistic multimodal combination offers unmatched capabilities for imaging multiple tissue properties and biomarkers with high resolution,penetration,and contrast.

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《光：科学与应用（英文版）》 |2019年第1期|1051-1062|共12页
作者
Elena Mercep; Joaquin LHerraiz; Xose Luis Dean-Ben; Daniel Razansky;
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作者单位

Faculty of Medicine;

Technical University of Munich;

Munich;

Germany;

iThera Medical GmbH;

Munich;

Germany;

Nuclear Physics Group and UPARCOS;

Complutense University of Madrid;

CEI Moncloa;

Madrid;

Spain;

Health Research Institute of Hospital Clinico San Carlos(IdISSC);

Madrid;

Spain;

Institute for Biological and Medical Imaging(IBMI);

Helmholtz Center Munich;

Neuherberg;

Germany;

Faculty of Medicine and Institute of Pharmacology and Toxicology;

University of Zurich;

Zurich;

Switzerland;

Institute for Biomedical Engineering and Department of Information Technology and Electrical Engineering;

ETH Zurich;

Zurich;

Switzerland;

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原文格式 PDF
正文语种 chi
中图分类计算技术、计算机技术;
关键词
reflectivity; rendering; details;

Transmission-reflection optoacoustic ultrasound(TROPUS)computed tomography of small animals

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