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《岭南心血管病杂志：英文版》
>The Profile of the Serum Levels of Inflammatory Cytokines TNF-a,IL-6,IL-10 and Captopril Intervention in Reno-hypertensive Rats
The Profile of the Serum Levels of Inflammatory Cytokines TNF-a,IL-6,IL-10 and Captopril Intervention in Reno-hypertensive Rats
Objectives To observe theprofile of the serum levels of inflammatory cytokinesinterleukin-6(IL-6) , tumor necrosis factor (TNF-α) andinterleukin-10 (IL-10) and evaluate the effects ofangiotensin- converting enzyme inhibitor-Captopril onthem in renohypertensive rats. Methods Using reformedtwo-kidney-one-clip(2K1C)method, renal hypertensiverats (RHR) were obtained by ligating abdominal aorta.30 Wistar rats were randomized into three groups;sham-operation group(A) ,model control group(B) andcaptopril group (C). All rats were killed after beinggiven the trial drugs 5 weeks, ELISA assays were usedto detect the levels of IL-6 and IL-10, the levels ofTNF-alpha were measured with radioimmunoassays.Results compared with group A, the left ventricularhypertrophy was aggravated in group B significantly,the ratio of left ventricle and body weight (LV/BW) was0.00318 ±0.00030 (B)and 0.00256 ±0.00040 (A)respectively (P 0.05);compared with group B, the LV/BW was 0.00266±0.00018 (C) and 0.00318±0.00030 (B) respectively(P 0.05);Conclusions Angiotensin converting enzymeinhibitor-captopril can lower the serum levels of pro-inflammatory cytokines IL-6 and TNF-α effectively,but can not increase the levels of anti-inflammatorycytokine IL-10, it suggests that captopril may have afeature to prevent or slow the development ofhypertensive complications by means of lowering thelevels of pro-inflammatory cytokines but not byincreasing anti-inflammatory cytokine IL-10.
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