In this paper, in view of the characteristics of the cold chain logistics distribution routes, we introduced the reverse logistics vehicle routing process with time window constraint into the cold chain logistics vehicle routing problem, taking into consideration cargo delivery and pick-up, the fixed vehicle cost and the transportation, the loss cost, energy cost, penalty cost and reputation cost in the event of breaking the time window of the customers in the cargo delivery process, built the reverse logistics considered cold chain logistics distribution cost model aiming at satisfying the time window constraint of the customers, and at the end, demonstrated the feasibility of the model through an empirical case study.%针对冷链物流配送路径的特性，将时间窗约束下的逆向物流车辆配送路径方法引入冷链物流配送路径优化问题中，在冷链物流配送路径问题中同时考虑送货和取货，不仅考虑车辆固定成本和运输成本，还考虑了在配送过程中货物的损耗成本、能源消耗成本以及违反客户时间窗带来的惩罚成本、信用损失等成本，建立了使得服务时间满足顾客时间窗约束的带逆向物流的冷链物流配送成本模型。最后以某生鲜食品连锁店为例，运用建立的模型进行路径规划，验证了模型的可行性。
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