组织工程支架的结构、 空间走向、 孔隙率是制约组织工程学发展的重要因素,支架内微流体流场直接影响着细胞的吸附、 增殖、 分化和流-固耦合引起的支架应力应变,且支架内微流体流场各种因素交互作用复杂,作用机制尚未明确,对其内部微管孔中的微流体流动特性的研究尚处于起步阶段.通过对组织工程支架内部流场及流体剪应力和新组织相互影响的研究情况进行阐述,发现在使用数值方法进行模拟仿真的同时,还缺少相应的物理实验验证,而快速成型技术和新材料的发展,对搭建微流体实验平台,探索骨支架及内部微流体流场的优化具有一定的工程意义.%Tissue engineering scaffold's structure, spatial trend, porosity is an important factor that restricts the development of tissue engineering.The micro-fluid flow field in the scaffold has a direct influence on the adsorption , proliferation, differentiation of cells and the stress and strain induced by fluid-structure coupling .Because of the complex interaction of various factors in the field , the functional mechanism is not yet clear .The research on the micro-fluid flow characteristics in the inner micro-pore is still in initial stage . By elaborated the research situation of the internal flow field in the bone tissue engineering scaffold and the interaction between fluid shear stress and neo-tissue, it was found that at the same time of the numerical method used to simulate the phenomenon , it was also lack of corresponding physical experiment .The development of Rapid prototyping technology and new materials has a certain engineer -ing significance to build a micro-fluid experimental platform , to explore the optimization of bone scaffold and internal micro-fluid flow field.
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